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G5773 Sigma

Galanin porcine

≥97% (HPLC), powder

  • CAS Number 88813-36-9

  • Empirical Formula (Hill Notation) C146H213N43O40

  • Molecular Weight 3210.52

  •  MDL number MFCD00133353

  •  PubChem Substance ID 24895230

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Galanins, Neuropeptides, Peptides and Proteins,
InChI Key   SLZIZIJTGAYEKK-UHFFFAOYSA-N
assay   ≥97% (HPLC)
form   powder
storage temp.   −20°C
Gene Information   pig ... GAL(397465)

Description

Amino Acid Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His-Arg-Ser-Phe-His-Asp-Lys-Tyr-Gly-Leu-Ala-NH2

Other Notes

Lyophilized from 0.1% TFA in H2O

Application

Galanin porcine has been used for the pre-absorption of anti-Gal serum, as control, to determine the specificity of immunoreaction during immunocytochemistry on brains obtained from river lampreys (Lampetra fluviatilis L.).

Biochem/physiol Actions

Studies show that galanin is capable of producing sustained but mild hyperglycemia in dogs. It also induces contraction in smooth muscle preparations obtained from fundus strip, ileum, colon and urinary bladder from rats. It shows structural similarities at the C-terminal to other neuropeptides, and thus, might also function as a neuropeptide. This peptide is a candidate hypothalamic-hypophysiotropic hormone, and is thought to affect the release of various pituitary hormones, such as growth hormone (GH), prolactin (PRL), and luteinizing hormone (LH).
Co-localized with acetylcholine and inhibits its release; inhibits the release of glutamic acid, decreases excitability of spinal neurons; blocks voltage-activated Ca2+ channels; linked to behavioral and cognitive deficits in Alzheimer′s disease.

General description

Galanin is a biologically active peptide found in porcine intestine, and is called so because of the presence of glycine and alanine at N- and C-terminals, respectively. Its C-terminal contains alanine amide. It is composed of 29 amino acids namely, Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His-Arg-Ser-Phe-His-Asp-Lys-Tyr-Gly-Leu-Ala-NH2. This peptide shows wide expression in peripheral and central nervous system. In brain, its predominant expression is in hypothalamus, especially in the nerve terminals of the median eminence.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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