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G5791 Sigma

Anti-phospho-Glycogen Synthase Kinase 3α/β (pTyr279/216) antibody produced in rabbit

affinity isolated antibody, aqueous glycerol solution

Synonym: Anti-phospho-GSK α/β (pTyr279/216)

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies for Neural Stem Cells,
species reactivity   mouse, rat, human
application(s)   dot blot: suitable
  indirect ELISA: suitable
  western blot: 1:1000 using MCF-7 cell extract
clone   polyclonal
antibody form   affinity isolated antibody
form   aqueous glycerol solution
mol wt   antigen mol wt 47-51 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... GSK3A(2931)
mouse ... Gsk3a(606496)
rat ... Gsk3a(50686)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic phosphopeptide derived from the regions of GSK-3α/β that contain tyrosine279/216.

General description

GSK-3 functions a serine-threonine kinase and modulates a wide range of cellular activities such as cell signaling, cell cycle, cell growth and differentiation. Mammalian GSK-3 has two isoforms, namely, GSK-3α and GSK-3 β. GSK-3α has been implicated in Alzheimer’s disease, whereas both, GSK-3α and GSK-3β have been implicated in leukemia . Anti-phospho-Glycogen Synthase Kinase 3α/β (p(Tyr279/216)) antibody is specific for phosphorylated forms of GSK-3α (51 kDa) and GSK-3β (47 kDa) that contain a phosphate moiety on tyrosine 279 and 216 respectively. The antibody does not bind to non-tyrosine phosphorylated GSK-3α/β protein. The product recognizes human, mouse and rat GSK-3α/β.

Physical form

Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free), and 0.05% sodium azide.

Application

Anti-phospho-Glycogen Synthase Kinase 3α/β (p(Tyr279/216)) antibody is suitable for use in indirect ELISA, dot blot and western blot (1:1000 using MCF-7 cell extract).

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