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G6004 Sigma

Glutathione Reductase from wheat germ

Type II, ≥0.08 units/mg protein

Synonym: GR, NAD(P)H: oxidized-glutathione oxidoreductase

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Description

Biochem/physiol Actions

A crucial flavoenzyme in the antioxidant defense system. Reduced glutathione (GSH) is used by glutathione peroxidase to detoxify hydrogen peroxide and in the process is converted to oxidized glutathione (GSSG). The GSSG is then recycled back to GSH by glutathione reductase (GR) using NADPH that is then converted to NADP+. The regenerated GSH is then available to detoxify more hydrogen peroxide. The enzyme uses FAD as a cofactor. GR and glutathione peroxidase may inhibit lipid peroxidation by functioning as antioxidant enzymes in sperm. Glutathione reductase shares a structural motif with a number of other proteins including aspartyl proteases, citrate synthase, EF hands, hemoglobins, lipocalins, and α/β hydrolases. GR is stimulated by melatonin and is reportedly irreversibly inhibited by a number of oxygen radical generating systems.

Quality

Crude

Unit Definition

One unit will reduce 1.0 μmole of oxidized glutathione per min at pH 7.6 at 25 °C. (Protein determined by biuret).

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All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

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Peer-Reviewed Papers
15

References

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GRSA Glutathione Reductase Assay Kit

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