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  • G6666 - Monoclonal Anti-GAP1IP4BP antibody produced in mouse

G6666 Sigma

Monoclonal Anti-GAP1IP4BP antibody produced in mouse

~2 mg/mL, clone GP-3, purified immunoglobulin, buffered aqueous solution



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to G Proteins, Antibodies to G Proteins and Cyclic Nucleotides,
species reactivity   human
application(s)   immunocytochemistry: suitable
  indirect ELISA: suitable
  microarray: suitable
  western blot: 1-2 μg/mL using human platelets extract
clone   GP-3, monoclonal
concentration   ~2 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG2b
mol wt   antigen mol wt ~100 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... RASA3(22821)
biological source   mouse
conjugate   unconjugated



recombinant human GAP1IP4BP

General description

GAP1IP4BP is an IP4 receptor and belongs to the GAP1 family of GTPases activating proteins for the Ras family of GTPases (GAPs). It has N-terminal coupled C2 domains, highly conserved central Ras GAP domains and a C-terminal IP4-binding pleckstrin homology (PH) domain. This PH domain is linked to a 26-amino acid Btk (Bruton’s tyrosine kinase) motif (PH/Btk). GAP1IP4BP is widely expressed in tissues and is localized to the plasma membrane.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.


Monoclonal Anti-GAP1IP4BP antibody produced in mouse is suitable for immunocytochemistry, indirect ELISA and microarray. It is also suitable for western blot analysis at a working concentration of 1-2μg/mL using human platelets extract.

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Biochem/physiol Actions

The binding activity of GAP1IP4BP depends on a functional PH/Btk domain. This domain binds to IP4 and targets the protein to the plasma membrane. This may facilitate the regulation of GAP1IP4BP by IP4. GAP1IP4BP is involved in the cation influx that is localized to the plasma membrane of human platelets.It plays a key role in Ca2+ regulation.

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