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G6669 Sigma

Monoclonal Anti-Gemin 2 antibody produced in mouse

clone 2E17, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-SIP1

Properties

Related Categories 2C-2E, Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Gene Regulation,
species reactivity   Xenopus, hamster, human, mouse, bovine, canine, rat, chicken
application(s)   immunocytochemistry: suitable
  immunoprecipitation: suitable
  microarray: suitable
  western blot: 0.5-1 μg/mL using HeLa cell extract
clone   2E17, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
mol wt   antigen mol wt ~32 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... SIP1(8487)
mouse ... Sip1(66603)
rat ... Sip1(84404)
conjugate   unconjugated

Description

Immunogen

recombinant human Gemin 2.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Application

Monoclonal Anti-Gemin 2 antibody produced in mouse is suitable for immunocytochemistry, immunoprecipitation and microarray. It is also suitable for western blot analysis at a working concentration of 0.5-1μg/mL using HeLa cell extract. The antibody is important in studying the role of the Gemin protein family in nuclear processes.

Features and Benefits

Antibody Bioguarantee
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Biochem/physiol Actions

GEMIN2 [gem (nuclear organelle) associated protein 2] encodes a protein that forms a multi-protein complex with the survival of motor neuron (SMN) protein. This complex also consists of several other gemin proteins. Gemin2 interacts directly with the SMN protein while Gemin4 and 6 require Gemin3 and 7 respectively for their interaction. The complex is involved in spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing and transcription in the nucleus.1,2,3 Deletion or mutation of SMN gene causes spinal muscular atrophy (SMA) disease that is characterized by degeneration of motor neurons and muscular atrophy.1

Price and Availability


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