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G7657 Sigma

Anti-GABA Transporter GAT-2 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

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Description

Immunogen

synthetic peptide corresponding to the C-terminal domain (amino acids 594-602) of rat GAT-2.

Application

Anti-GABA Transporter GAT-2 antibody produced in rabbit is suitable for immunohistochemistry.

Biochem/physiol Actions

GAT-2 is a transporter for the selective uptake of γ-Aminobutyric acid (GABA). It belongs to a family of Na+ and Cl- co-dependent transporters, which include GAT-1, GAT-3 and BGT-1 transporters. These transporters have a molar mass of 67kDa each and contain 12 transmembrane regions. GABA is the major inhibitory neurotransmitter in the CNS and a neuromodulator in certain peripheral tissues.

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