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G7784 Sigma

GROγ human

recombinant, expressed in E. coli, ≥97% (SDS-PAGE), cell culture tested

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Properties

Related Categories Cell Culture, Growth Factors and Cytokines, Miscellaneous, Reagents and Supplements
recombinant   expressed in E. coli
assay   ≥97% (SDS-PAGE)
potency   0.05-0.5 ng/mL ED50/EC50
impurities   endotoxin, tested
suitability   cell culture tested
storage temp.   −20°C
Gene Information   human ... CXCL3(2921)

Description

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin

Biochem/physiol Actions

The product of the human GRO gene is a cytokine with inflammatory and growth-regulatory properties. GROγ shares 86% identity at the amino acid level with GROα. Compared with GROalpha, there are 15 amino acid substitutions in GROγ. The substitution of leucine at amino acid 54 in GROγ for proline in GROalpha changes the protein conformation to GROγ. GROγ is a member of the chemokine-alpha (C-X-C) subfamily. GROγ is found on chromosome 4q21. IL-1 and TNFalpha induce the maximum expression of GROγ mRNA in human cell lines. GROγ is expressed in monocytes, fibroblasts, melanocytes, keratinocytes, neutrophils, lymphocytes and umbilical vein endothelial cells. GROγ is a potent chemoattractant for human neutrophils, but not human monocytes.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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G0657 GROα human, ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell culture tested

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