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G8035 Sigma

Anti-Glial Cell-derived Neurotrophic Factor (GDNF) antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Description

Immunogen

recombinant human GDNF expressed in Escherichia coli.

General description

The antibody neutralizes the biological activity of recombinant human GDNF.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Preparation Note

Purified using protein G.

Biochem/physiol Actions

Glial cell-derived neurotrophic factor is a potent neurotrophic factor that is important for the maintenance, regeneration and survival of specific neuronal cells including autonomic neurons, motoneurons, noradrenergic and seotonergic neurons. Additionally, it promotes the invasion and metastatic behavior of certain types of cancers by activating ERK, p38, JNK and AP-1 mediated cell signaling.

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