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G8270 Sigma

D-(+)-Glucose

≥99.5% (GC)

Synonym: Dextrose

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anhydrous, 96%

<SC>D</SC>-(+) Glucose

analytical standard

<SC>D</SC>-(+)-Glucose

BioXtra, ≥99.5% (GC)

<SC>D</SC>-(+)-Glucose

ACS reagent

<SC>D</SC>-(+)-Glucose

powder, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99.5%

Safety & Documentation

Safety Information

WGK Germany 
1
RTECS 
LZ6600000

Protocols & Articles

Articles

Determination of Water Content in D-(+)Glucose anhydrous Using Karl Fischer Titration

Anhydrous glucose hardly dissolves in the methanolic media used in KF titration. To improve the solubility and thus shorten the titration time, either the titration should be carried out at 50�C, or ...
Keywords: Pharmaceutical, Titrations

Determination of Water Content in Dextrose (anhydrous) Using Karl Fischer Titration

Carbohydrates comprise diverse compounds, mono-, di- and polysaccharides. Mono- and disaccharides dissolve in Methanol or solvent mixtures and can thus be titrated. If only adherent water is to be de...
Keywords: Pharmaceutical, Titrations

Protocols

Enzymatic Assay of Invertase

2. SCOPE This procedure applies to all products that have specification for the enzymatic activity of Invertase at Sigma-Aldrich Saint Louis.
Keywords: Biochemistry, Enzyme activity, Enzymology

Peer-Reviewed Papers

References

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Notch signaling maintains T cell memories. Miller AM and Schoenberger SP Nat. Med. 21(1), 16-8, (2015)

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Regulation of glucose homeostasis using radiogenetics and magnetogenetics in mice. Leibiger IB and Berggren PO Nat. Med. 21(1), 14-6, (2015)

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Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity. Bouret S, Levin BE, and Ozanne SE Physiol. Rev. 95(1), 47-82, (2015)

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Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions. Thakran S, Zhang Q, Morales-Tirado V, et al. Invest. Ophthalmol. Vis. Sci. 56(1), 177-84, (2015)

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Preliminary results of a new test for rapid diagnosis of septic arthritis with use of leukocyte esterase and glucose reagent strips. Omar M, Ettinger M, Reichling M, et al. J. Bone Joint Surg. Am. 96(24), 2032-7, (2014)

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Notch controls the survival of memory CD4+ T cells by regulating glucose uptake. Maekawa Y, Ishifune C, Tsukumo S, et al. Nat. Med. 21(1), 55-61, (2015)

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Extracellular and cell-associated forms of Gluconobacter oxydans dextran dextrinase change their localization depending on the cell growth. Sadahiro J, Mori H, Saburi W, et al. Biochem. Biophys. Res. Commun. 456(1), 500-5, (2015)

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Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells. Carey BW, Finley LW, Cross JR, et al. Nature 518(7539), 413-6, (2015)

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Elevated expression of glutaminase confers glucose utilization via glutaminolysis in prostate cancer. Pan T, Gao L, Wu G, et al. Biochem. Biophys. Res. Commun. 456(1), 452-8, (2015)

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Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock. Muoio DM Cell 159(6), 1253-62, (2014)

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Modest hyperglycemia prevents interstitial dispersion of insulin in skeletal muscle. Kolka CM, Castro AV, Kirkman EL, et al. Metabolism 64(2), 330-7, (2015)

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Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice. Ojo OO, Srinivasan DK, Owolabi BO, et al. Biochim. Biophys. Acta 1850(1), 80-7, (2015)

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Distinct pathways of cholesterol biosynthesis impact on insulin secretion. Zúñiga-Hertz JP, Rebelato E, Kassan A, et al. J. Endocrinol. 224(1), 75-84, (2015)

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Regulation of 18F-FDG accumulation in colorectal cancer cells with mutated KRAS. Iwamoto M, Kawada K, Nakamoto Y, et al. J. Nucl. Med. 55(12), 2038-44, (2014)

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Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction. Agouni A, Tual-Chalot S, Chalopin M, et al. Biochem. Pharmacol. 92(4), 607-17, (2014)

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Transgenic silkworms expressing human insulin receptors for evaluation of therapeutically active insulin receptor agonists. Matsumoto Y, Ishii M, Ishii K, et al. Biochem. Biophys. Res. Commun. 455(3-4), 159-64, (2014)

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The effect of glucose concentration and sodium phenylbutyrate treatment on mitochondrial bioenergetics and ER stress in 3T3-L1 adipocytes. Tanis RM, Piroli GG, Day SD, et al. Biochim. Biophys. Acta 1853(1), 213-21, (2015)

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Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling. Zhdanov AV, Waters AH, Golubeva AV, et al. Exp. Cell Res. 330(1), 13-28, (2015)

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DPP IV inhibitor suppresses STZ-induced islets injury dependent on activation of the IGFR/Akt/mTOR signaling pathways by GLP-1 in monkeys. Zhang Y, Chen Y, Cheng J, et al. Biochem. Biophys. Res. Commun. 456(1), 139-44, (2015)

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Improvement of insulin signaling in myoblast cells by an addition of SKIP-binding peptide within Pak1 kinase domain. Ijuin T and Takenawa T Biochem. Biophys. Res. Commun. 456(1), 41-6, (2015)

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Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells. Aragón F, Karaca M, Novials A, et al. Biochim. Biophys. Acta 1850(2), 343-51, (2015)

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L-Carnitine intake prevents irregular feeding-induced obesity and lipid metabolism disorder. Wu T, Guo A, Shu Q, et al. Gene 554(2), 148-54, (2015)

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Propofol (Diprivan®) and Intralipid® exacerbate insulin resistance in type-2 diabetic hearts by impairing GLUT4 trafficking. Lou PH, Lucchinetti E, Zhang L, et al. Anesth. Analg. 120(2), 329-40, (2015)

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Metabolic efficiency promotes protection from pressure overload in hearts expressing slow skeletal troponin I. Carley AN, Taglieri DM, Bi J, et al. Circ. Heart Fail. 8(1), 119-27, (2015)

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Benzophenone C- and O-glucosides from Cyclopia genistoides (Honeybush) inhibit mammalian α-glucosidase. Beelders T, Brand DJ, de Beer D, et al. J. Nat. Prod. 77(12), 2694-9, (2014)

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Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Arruda AP, Pers BM, Parlakgül G, et al. Nat. Med. 20(12), 1427-35, (2014)

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Regeneration of insulin-producing pancreatic cells using a volatile bioactive compound and human teeth. Okada M, Imai T, Yaegaki K, et al. J. Breath Res. 8(4), 046004, (2014)

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Stem-cell success aids diabetes fight. Ledford H Nature 514(7522), 281, (2014)

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20 years of leptin: connecting leptin signaling to biological function. Allison MB and Myers MG J. Endocrinol. 223(1), T25-35, (2014)

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Phthalate exposure in utero causes epigenetic changes and impairs insulin signalling. Rajesh P and Balasubramanian K J. Endocrinol. 223(1), 47-66, (2014)

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Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Suez J, Korem T, Zeevi D, et al. Nature, doi:10.1038/nature13793, (2014)

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Analysis of the effect of canagliflozin on renal glucose reabsorption and progression of hyperglycemia in zucker diabetic Fatty rats. Kuriyama C, Xu JZ, Lee SP, et al. J. Pharmacol. Exp. Ther. 351(2), 423-31, (2014)

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Andrographolide prevents high-fat diet-induced obesity in C57BL/6 mice by suppressing the sterol regulatory element-binding protein pathway. Ding L, Li J, Song B, et al. J. Pharmacol. Exp. Ther. 351(2), 474-83, (2014)

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Strategies in the prevention of the formation of postoperative adhesions in digestive surgery: a systematic review of the literature. Robb WB and Mariette C Dis. Colon Rectum 57(10), 1228-40, (2014)

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Metabolic engineering of Acinetobacter baylyi ADP1 for improved growth on gluconate and glucose. Kannisto M, Aho T, Karp M, et al. Appl. Environ. Microbiol. 80(22), 7021-7, (2014)

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Heterologous expression of AtPAP2 in transgenic potato influences carbon metabolism and tuber development. Zhang Y, Sun F, Fettke J, et al. FEBS Lett. 588(20), 3726-31, (2014)

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Ovarian tumor-initiating cells display a flexible metabolism. Anderson AS, Roberts PC, Frisard MI, et al. Exp. Cell Res. 328(1), 44-57, (2014)

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Fat-constrained 18F-FDG PET reconstruction in hybrid PET/MR imaging. Prevrhal S, Heinzer S, Wülker C, et al. J. Nucl. Med. 55(10), 1643-9, (2014)

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Utilization of by-products derived from bioethanol production process for cost-effective production of lactic acid. Moon SK, Wee YJ, and Choi GW J. Ind. Microbiol. Biotechnol. 41(10), 1525-31, (2014)

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Comparison of the therapeutic effect between sodium bicarbonate and insulin on acute propafenone toxicity. Yi HY, Lee JY, Lee WS, et al. Am. J. Emerg. Med. 32(10), 1200-7, (2014)

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Characterization of a mutant glucose isomerase from Thermoanaerobacterium saccharolyticum. Xu H, Shen D, Wu XQ, et al. J. Ind. Microbiol. Biotechnol. 41(10), 1581-9, (2014)

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Promoter sequences direct cytoplasmic localization and translation of mRNAs during starvation in yeast. Zid BM and O'Shea EK Nature 514(7520), 117-21, (2014)

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Canagliflozin, a sodium glucose co-transporter 2 inhibitor, reduces post-meal glucose excursion in patients with type 2 diabetes by a non-renal mechanism: results of a randomized trial. Stein P, Berg JK, Morrow L, et al. Metabolism 63(10), 1296-303, (2014)

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Adiponectin stimulates Rho-mediated actin cytoskeleton remodeling and glucose uptake via APPL1 in primary cardiomyocytes. Palanivel R, Ganguly R, Turdi S, et al. Metabolism 63(10), 1363-73, (2014)

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Feasibility of 18F-FDG PET as a noninvasive diagnostic tool of muscle denervation: a preliminary study. Lee SH, Oh BM, Lee G, et al. J. Nucl. Med. 55(10), 1737-40, (2014)

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The role of the kidneys in glucose homeostasis in type 2 diabetes: clinical implications and therapeutic significance through sodium glucose co-transporter 2 inhibitors. Wilding JP Metabolism 63(10), 1228-37, (2014)

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α-Acetolactate synthase of Lactococcus lactis contributes to pH homeostasis in acid stress conditions. Zuljan FA, Repizo GD, Alarcon SH, et al. Int. J. Food Microbiol. 188, 99-107, (2014)

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High-yield recombinant xylanase production by Aspergillus nidulans under pyridoxine limitation. Müller M, Segato F, Prade RA, et al. J. Ind. Microbiol. Biotechnol. 41(10), 1563-70, (2014)

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High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: role in diabetic retinopathy. Kim DI, Park MJ, Lim SK, et al. Arch. Biochem. Biophys. 560, 36-43, (2014)

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Weight-loss surgery: A gut-wrenching question. Hughes V Nature 511(7509), 282-4, (2014)

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Adipsin is an adipokine that improves β cell function in diabetes. Lo JC, Ljubicic S, Leibiger B, et al. Cell 158(1), 41-53, (2014)

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Plant-fungal ecology. Niche engineering demonstrates a latent capacity for fungal-algal mutualism. Hom EF and Murray AW Science 345(6192), 94-8, (2014)

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High glucose modifies transient receptor potential canonical type 6 channels via increased oxidative stress and syndecan-4 in human podocytes. Thilo F, Lee M, Xia S, et al. Biochem. Biophys. Res. Commun. 450(1), 312-7, (2014)

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LMO4 is required to maintain hypothalamic insulin signaling. Pandey NR, Zhou X, Zaman T, et al. Biochem. Biophys. Res. Commun. 450(1), 666-72, (2014)

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14,15-EET promotes mitochondrial biogenesis and protects cortical neurons against oxygen/glucose deprivation-induced apoptosis. Wang L, Chen M, Yuan L, et al. Biochem. Biophys. Res. Commun. 450(1), 604-9, (2014)

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Activation of activin type IB receptor signals in pancreatic β cells leads to defective insulin secretion through the attenuation of ATP-sensitive K+ channel activity. Nomura M, Morinaga H, Zhu HL, et al. Biochem. Biophys. Res. Commun. 450(1), 440-6, (2014)

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In Saccharomyces cerevisiae fructose-1,6-bisphosphate contributes to the Crabtree effect through closure of the mitochondrial unspecific channel. Rosas-Lemus M, Uribe-Alvarez C, Chiquete-Félix N, et al. Arch. Biochem. Biophys. 555-556, 66-70, (2014)

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Effects of grinding method, particle size, and physical form of the diet on gastrointestinal morphology and jejunal glucose transport in laying hens. Röhe I, Ruhnke I, Knorr F, et al. Poult. Sci. 93(8), 2060-8, (2014)

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[The role of epigenetic modification in glucose and lipid metabolism]. Li M, Cao L, and Yang Y Yi Chuan 36(3), 200-7, (2014)

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Effect of continuous positive airway pressure on type 2 diabetes mellitus and glucose metabolism. Gallegos L, Dharia T, and Gadegbeku AB Hosp. Pract. (Minneap) 42(2), 31-7, (2014)

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Zinc-rs13266634 and the arrival of diabetes pharmacogenetics: the "zinc mystique". Maruthur NM and Mitchell BD Diabetes 63(5), 1463-4, (2014)

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Dextrose 10% in the treatment of out-of-hospital hypoglycemia. Kiefer MV, Gene Hern H, Alter HJ, et al. Prehosp. Disaster Med. 29(2), 190-4, (2014)

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Mesoamerica's mystery killer. Cohen J Science 344(6180), 143-7, (2014)

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Metabolic quirks yield tumour hope. Ledford H Nature 508(7495), 158-9, (2014)

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Application of the finite difference method to model pH and substrate concentration in a double-chamber microbial fuel cell. Zhang L and Deshusses M Environ. Technol. 35(9-12), 1064-76, (2014)

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Increasing evidence that diet impacts cognitive function. Reduce refined carbohydrates and sugar intake, increase protein and "good" fats consumption to help prevent cognitive impairment. Duke. Med. Health. News. 19(11), 5-6, (2013)

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Glucose transport in brain - effect of inflammation. Jurcovicova J Endocr. Regul. 48(1), 35-48, (2014)

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Optimization of complex fermentation media for glucose oxidase production using statistical approach. Gunny AA, Arbain D, and Sithamparam L Pak. J. Biol. Sci. 16(18), 960-4, (2013)

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Bioconversion of oil palm frond by Aspergillus niger to enhances it's fermentable sugar production. Lim SH and Ibrahim D Pak. J. Biol. Sci. 16(18), 920-6, (2013)

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[Glucose, ascorbic acid and hydrogen peroxide as ingredients of endoscopic hemostasis in bleeding ulcer]. Timen LIa, Machneva TV, Trubitsina IE, et al. Eksp. Klin. Gastroenterol. (5), 89-92, (2013)

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[Carbohydrate restriction in the larval diet causes oxidative stress in adult insects of Drosophila melanogaster]. Rovenko BM, Lushchak VI, and Lushchak OV Ukr. Biokhim. Zh. 85(5), 61-72, (2013)

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[Substrate specificity of Cryptococcus albidus and Eupenicillium erubescens alpha-L-rhamnosidases]. Hudzenko OV and Varbanets' LD Ukr. Biokhim. Zh. 85(5), 17-26, (2013)

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[Growth characteristics of Fusarium poae (Peck) Wollenw. and Penicillium funiculosum Thom strains]. Kurchenko IN, Pavlichenko AK, and Iur'eva EM Mikrobiol. Z. 75(5), 47-51, (2013)

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[Kinetic characteristics of alpha-L-rhamnosidase of Eupenicillium erubescens]. Gudzenko EV and Varbanets LD Mikrobiol. Z. 75(5), 27-32, (2013)

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Compatibility of amiodarone hydrochloride with vasopressin during simulated Y-site administration. Ramaley CC, Li F, and Du C Int. J. Pharm. Compd. 17(5), 436-8, (2013)

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[Alternative type of fuel--biobutanol]. Tigunova EA, Shul'ga SM, and Blium IaB Tsitol. Genet. 47(6), 51-71, (2013)

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[Glucose gel for hypoglycemia in the newborn]. Retbi JM Soins. Pediatr. Pueric. (275), 8, (2013)

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[Endocrinological aspects of diabetes mellitus in the elderly]. Hashizume K Nihon Rinsho. 71(11), 1941-7, (2013)

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[Insulin secretion and insulin resistance]. Ohta Y and Tanizawa Y Nihon Rinsho. 71(11), 1936-40, (2013)

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SGLT2 inhibitors to control glycemia in type 2 diabetes mellitus: a new approach to an old problem. Jabbour SA Postgrad. Med. 126(1), 111-7, (2014)

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Surgery versus snacking as treatment of insulinoma. Jaiswal DD and Wallace EA Mayo Clin. Proc. 89(1), e7-8, (2014)

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Intestinal glucose transport in the critically ill--eavesdropping on a dialogue. Miskovitz P Crit. Care Med. 42(1), 202-3, (2014)

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[Hypothalamic orexin system regulates energy and glucose metabolism]. Tsuneki H and Sasaoka T Nippon. Yakurigaku Zasshi. 142(6), 316-7, (2013)

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Child neurology: differential diagnosis of a low CSF glucose in children and young adults. Leen WG, de Wit CJ, Wevers RA, et al. Neurology 81(24), e178-81, (2013)

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Cooperation between brain and islet in glucose homeostasis and diabetes. Schwartz MW, Seeley RJ, Tschöp MH, et al. Nature 503(7474), 59-66, (2013)

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The role of kidney in glucose homeostasis--SGLT2 inhibitors, a new approach in diabetes treatment. Andrianesis V and Doupis J Expert Rev. Clin. Pharmacol. 6(5), 519-39, (2013)

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[Proton spectroscopy of the lower leg muscles before and after exercise]. Karcz P and Urbanik A Prz. Lek. 70(5), 286-92, (2013)

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[Effect of glyphosate on the energy exchange in carp organs]. Zhidenko AA, Bibchuk EV, and Barbukho EV Ukr. Biokhim. Zh. 85(3), 22-30, (2013)

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Medicine. Why does gastric bypass surgery work? Berthoud HR Science 341(6144), 351-2, (2013)

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[Thromboresistance of glucose-containing hydrogels]. Valuev IL, Valuev LI, Vanchugova LV, et al. Prikl. Biokhim. Mikrobiol. 49(3), 319-21, (2013)

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[Transformation of humic substances of highly oxidized brown coal by the basidiomycetes fungi Trametes hirsuta and Trametes maxima]. Kliaĭn OI, Kulikova NA, Konstantinov AI, et al. Prikl. Biokhim. Mikrobiol. 49(3), 292-300, (2013)

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Can prenatal nutritional constraints in the chicken embryo have long-term effects on the post-hatch performance and glucose metabolism? Willems E, Koppenol A, Lesuisse J, et al. Commun. Agric. Appl. Biol. Sci. 78(1), 79-84, (2013)

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[Transcript profile of converting xylose and glucose to ethanol by Candida shehatae]. Xiong X, Cai P, Xu Y, et al. Wei Sheng Wu Xue Bao 53(4), 339-45, (2013)

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[Production of L-lactic acid from pentose by a genetically engineered Escherichia coli]. Zhao J, Xu L, Wang Y, et al. Wei Sheng Wu Xue Bao 53(4), 328-37, (2013)

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Recurrent pancreatitis in an icodextrin-based peritoneal dialysis patient. Yet another case report. Hayat A, Thaneeru P, Priest P, et al. N. Z. Med. J. 126(1377), 67-9, (2013)

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[Mitokorrektine stimulates angiogenesis in vitro]. Harmanchuk LV, Makarenko OM, Khranovs'ka NM, et al. Fiziol. Zh. 59(2), 52-8, (2013)

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[Current topics of purification and composition of dialysis fluid]. Tomo T Nihon Jinzo Gakkai Shi 55(4), 498-501, (2013)

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Merck 14,4459

Beil. 1,IV,4302 / Beil. 31,83

FT-IR 1 (1), 190:B / FT-NMR 1 (1), 300:A / NMR-Reference 2 (2), 907:C / RegBook 1 (1), 193:D / Sax 6, 1477 / Structure Index 1, 26:D:5

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