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G8415 Sigma

L-Glutamic acid

from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%

Synonym: (S)-2-Aminopentanedioic acid, Glu

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Properties

Related Categories Amino Acid Library Collection, Amino Acids, Amino Acids & Vitamins, Amino Acids and Vitamins, Analytical/Chromatography,
biological source   from non-animal source
InChI Key   WHUUTDBJXJRKMK-VKHMYHEASA-N
assay   98.5-100.5%
form   powder
impurities   endotoxin, tested
mp   205 °C (dec.)(lit.)
solubility   1 M HCl: soluble100 mg/mL
suitability   meets EP testing specifications
  suitable for cell culture
Gene Information   human ... CCR2(1231), GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK5(2901), GRIN2B(2904), GRM2(2912), SLC1A1(6505), SLC1A2(6506)
rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grm1(24414), Grm2(24415), Grm3(24416), Grm4(24417), Grm5(24418), Grm6(24419), Grm7(81672), Slc1a2(29482)

Description

Biochem/physiol Actions

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter. Glutamic acid also plays a key role in many metabolic pathways. It is converted to α-ketoglutarate, a key component of the TCA cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids. In cells, glutamine is converted to glutamate by the enzyme glutaminase.

Packaging

1 kg in poly bottle

10 mg in glass bottle

100 g in poly bottle

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Glutamine Metabolism is Dysregulated in Many Cancer Cells

Proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metab...
Keywords: Aerobic, Biofiles, Cancer, Citric Acid Cycle, Gene expression, Glycolysis, Metabolism, Metabolites, PAGE, Phosphorylations, Support, Transcription

Related Content

Amino Acids Reference Chart

The hydrophobicity index is a measure of the relative hydrophobicity, or how soluble an amino acid is in water. In a protein, hydrophobic amino acids are likely to be found in the interior, whereas h...

Peer-Reviewed Papers
15

References

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