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G8546 Sigma

p38γ, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: ERK3, ERK6, MAPK12, PRKM12, SAPK3

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Properties

Related Categories Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
recombinant   expressed in baculovirus infected Sf9 cells
grade   PRECISIO® Kinase
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   56-76 nmol/min·mg
mol wt   mol wt ~71 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... MAPK12(6300)

Description

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Biochem/physiol Actions

p38γ is a key protein of the MAPK (mitogen-activated protein kinase) pathway and is involved in cell differentiation, growth, cycle and apoptosis and inflammation. It is essential for normal localization of polo-like kinase 1 (Plk1) at the kinetochore. This protein facilitates mitotic cell viability and suppresses chromosomal instability. Studies suggest that this protein negatively controls the expression of GLUT4 (glucose transporter) and the uptake of glucose mediated by contraction in adult skeletal muscles.

General description

p38γ, commonly known as MAPK12 (mitogen-activated protein kinase 12), is one of the four isoforms of the p38 MAPK family. This isoform shows predominant expression in skeletal muscle and is controlled by exercise.

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Protocols & Articles

Articles

Parkinson's Disease

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting more than 6 million people worldwide. PD is a slowly progressing motor system neurod...
Carolyn L. Crankshaw
BioFiles v7 n2, 2011, 16–20
Keywords: Alzheimer Disease, Apoptosis, Chromatin immunoprecipitation, Clinical, Degradations, Dopamine agents, Gene expression, Parkinson Disease, Polymorphisms

Peer-Reviewed Papers
15

References

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