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G8903 Sigma

Ghrelin rat

lyophilized powder

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, GH-RH, Growth Hormone Releasing Factors, Neuropeptides,
form   lyophilized powder
color   white
solubility   1% acetic acid: soluble1 mg/mL
  water: soluble1 mg/mL
storage temp.   −20°C
Gene Information   rat ... Ghrl(59301)

Description

Amino Acid Sequence

Gly-Ser-Ser(O-n-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg

Biochem/physiol Actions

Endogenous ligand to the orphan growth-hormone secretagogue receptor that stimulates the release of growth hormone from the pituitary.

Ghrelin acts as a ligand for G-protein coupled receptor, GHS-R1A (growth hormone secretagogue receptor), and controls energy utilization and feeding. This peptide is involved in enhancing the value of rewarding foods, drugs and alcohol. In rats with diabetes, the expression of ghrelin increased as a result of cachexia. In rats with ovariectomy, the expression of this peptide decreased in the endometrium. This peptide controls cognitive functions and has neuroprotective roles in neurodegenerative disorders. In cultured cortical neuronal networks, ghrelin increases the rate of synapse formation and activity development.

Other Notes

Lyophilized from 0.1% TFA in H2O

Physical form

Lyophilized from 0.1% aqueous TFA

Application

Ghrelin rat has been used for intraperitoneal injections, and microinjections in rats to study its effects on celiac disease, and passive avoidance learning (PAV) and spatial learning, respectively. It has also been used for intracerebroventricular injection in rats to study its influence on penicillin-induced epileptiform activity in rat.

General description

Ghrelin is a gut-brain orexigenic peptide that functions in hunger signaling. This peptide is prominently synthesized by stomach and transported to brain. However, a specific subset of hypothalamic neurons also produces this peptide. It is expressed in gastrointestinal tract, hypothalamic arcuate nucleus, pituitary, kidney, liver, heart, lung and adipose tissue This peptide is composed of 28 amino acids, and its Ser3 residue is N-octanoylated.

Price and Availability


Amplified Detection

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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