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  • G8913 - Anti-Glutamate Receptor NMDAR1 (NR1) antibody produced in rabbit

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G8913 Sigma

Anti-Glutamate Receptor NMDAR1 (NR1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Huntington’s Disease Research, Antibodies for Neurotransmission,
species reactivity   mouse, rat, human
application(s)   western blot: 1:2,000 using extract of a rat brain synaptosomal fraction.
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 116 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... GRIN1(2902)
mouse ... Grin1(14810)
rat ... Grin1(24408)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to the C-terminal region of rat NMDAR1 (amino acids 918-938). This sequence is identical in mouse NR1, human NR1 (short and long forms), and rat NR1 isoforms NR1b, NR1c, and NR1f.

General description

NMDAR1 is a subunit of N-methyl D-aspartate (NMDA) receptor which is a subtype of glutamate-gated ion channels with high calcium permeability. NMDA receptors have unique voltage-dependent sensitivity to magnesium and are modified by glycine. It has a pivotal role in neuronal development, pathogenesis of acute and chronic neurodegenerative disorders, synaptic plasticity as well as memory acquisition and learning. Anti-glutamate receptor NMDAR1 (NR1) antibody can be used for studying the expression and function of NMDAR1 in different cell types and tissues as well as to compare its expression pattern with physiological functions or pathological conditions. Rabbit anti-glutamate receptor NMDAR1 (NR1) antibody reacts specifically with NMDAR1 (116kD) derived from rat brain.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Application

Anti-glutamate receptor NMDAR1 (NR1) antibody can be used as a primary antibody in western blotting. It can also be used to identify NR1 from rat brain synaptosomal fraction by using immunoblotting.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles

Articles

Huntington's Disease

Huntington's disease (HD) is an autosomal dominant, late-onset neurodegenerative disorder characterized by a selective neuronal cell death in the cortex and striatum leading to cognitive dysfunction,...
Carolyn L. Crankshaw
BioFiles v7 n2, 2011, 9–14
Keywords: Apoptosis, Huntington Disease, Transcription

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