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G9002 Sigma

Guanosine 5′-triphosphate tris salt

≥93% (HPLC), powder

Synonym: GTP

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Properties

Related Categories Biochemicals and Reagents, Cofactors, Enzymes, Inhibitors, and Substrates, Phosphate Donors
InChI Key   UXNOYHQEVMMTDK-CYCLDIHTSA-N
assay   ≥93% (HPLC)
form   powder
color   white
solubility   H2O: soluble 50 mg/mL clear to slightly hazy, colorless
  H2O: soluble 50 mg/mL clear to slightly hazy, colorless
shipped in   dry ice
storage temp.   −20°C

Description

Biochem/physiol Actions

GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

The translocation of proteins into the mitochondria matrix involves the interactions of both GTP and ATP. These imported proteins are important in several pathways regulated in mitochondria. GTP is involved in the initiation of peptide synthesis during the binding of formylmethionyl-tRNA (F-met-tRNA) to the ribosome. It is also involved in polypeptide chain elongation. GTP is hydrolyzed by tubulin and its hydrolysis is accompanied by microtubule assembly.

Packaging

10 mg in glass bottle

25 mg in poly bottle

100, 500 mg in glass bottle

Preparation Note

Prepared from Catalog No. G8877.

Application

GTP from Sigma was used
• in a study to induce dissociation of the endogenous neuropeptide galanin from its binding sites prior to incubation with radiolabeled ligand
• as a substrate along with FtsZ in a colorimetric assay to detect GTPase activity to test polymerization of FtsZ, the prokaryotic ortholog of tubulin, in the absence of Na+
• as a pipette solution for patch-clamp Ca2+ measurements in a study
• as an internal standard during the analysis of water-soluble inositol phosphate

Price and Availability


Laboratory Gloves

Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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