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  • G9038 - Anti-Glutamate Receptor NMDAR2A (NR2A) antibody produced in rabbit

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G9038 Sigma

Anti-Glutamate Receptor NMDAR2A (NR2A) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Neurotransmission, Antibodies to Glutamate Receptors,
species reactivity   rat, human, mouse
application(s)   microarray: suitable
  western blot: 1:3,000 using extract of rat brain synaptosomal fraction.
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 170 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... GRIN2A(2903)
mouse ... Grin2a(14811)
rat ... Grin2a(24409)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to the C-terminal region of rat NMDAR2A (amino acids 1449-1464). This sequence is identical in human and mouse NMDAR2A and similar to the NMDAR2B sequence (70% identity).

General description

N-methyl-D-aspartate (NMDA) receptors are made up of NMDAR1 (NR1) and NMDAR2A-NMDAR2D (NR2A-NR2D) subunits. The glutamate receptor, N-methyl D-aspartate 2A (GRIN2A) gene encodes the 2A subunit of the NMDA receptor. The NMDA receptors are made up of NR1 and at least one subunit of the NR2 class, forming a hetero-pentamer complex.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Specificity

The antibody reacts with NMDAR2A and may recognize the NMDAR2B subunit (NR2B).

Application

Anti-Glutamate Receptor NMDAR2A (NR2A) antibody produced in rabbit is suitable as a primary antibody for immunoblotting using whole-tissue lysates or crude synaptosomal fractions of hippocampal slices from mice. It is suitable for immunoblotting at a working dilution of 1:3000 using a synaptosomal fraction of rat brain. It is also suitable for microarray analysis.

Biochem/physiol Actions

The NMDA receptors are permeable to Ca2+, Na+ and K+ and contain modulatory sites for Mg2+ , Zn2+, glycine, protons, and polyamines. These receptors are regulated by tyrosine phosphorylation. It is required for long term potentiation (LTP), a mechanism that facilitates learning and memory.

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