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G9269 Sigma

Anti-Glial Fibrillary Acidic Protein antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-GFAP

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies against Proteins, Bioactives, Markers, and Receptors for Stem Cell Biology, Antibodies against Proteins/Bioactives/Markers/Receptors for Stem Cell Biology, Antibodies for Cell Biology,
species reactivity   rat, human
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:80 using brain sections
  microarray: suitable
  western blot: 1:500 using brain extract
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... GFAP(2670)
rat ... Gfap(24387)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

GFAP from human brain

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Specificity

The product reacts specifically with GFAP and labels astrocytes, glial cells and glial cell derived tumors in immunohistochemical staining. The antibody reacts with glial specific antigen in alcohol or formalin-fixed, paraffin-embedded human or animal tissue sections.

Application

Anti-Glial Fibrillary Acidic Protein antibody produced in rabbit is suitable for:
• immunohistochemical staining at a working dilution of 1:400 using rat brain sections
• immunohistochemical staining of human brain tumor tissue specimens to identify the cells expressing AQP4 (Aquaporin-4)
• immunofluorescence using brain section from mice
The antibody is suitable for immunohistochemistry at a working dilution of 1:80 using alcohol- and formalin-fixed, paraffin-embedded sections of human or animal brain tissue. It is also suitable for indirect immunoblotting at a working dilution of 1:500 using human brain extract blot and microarray.

Biochem/physiol Actions

The gene GFAP encodes an intermediate filament protein (50kDa) of mature astrocytes, which may be used as a marker for distinguishing astrocytes from other glial cells during development of the central nervous system. Defects in this gene causes Alexander disease. It is a rare disorder of astrocytes in the central nervous system.

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