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  • G9790 - Anti-Glutamate Receptor 2/3, Metabotropic (mGluR2/3) antibody produced in rabbit

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G9790 Sigma

Anti-Glutamate Receptor 2/3, Metabotropic (mGluR2/3) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Neurotransmission, Antibodies to Glutamate Receptors,
species reactivity   mouse, feline, rat
application(s)   immunohistochemistry (frozen sections): 1:500
  immunoprecipitation: 1:100
  indirect immunofluorescence: 1:500
  western blot: 1:1,000
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   mouse ... Grm2(108068)
rat ... Grm2(24415)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to the C-terminal region (13 amino acids) of mGluR2/3.

General description

The metabotropic glutamate receptors consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors, involved in the fast excitatory synaptic transmission. Glutamate also regulates ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins, called metabotropic glutamate receptors.

Physical form

Solution in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100μg/mL BSA, and 50% glycerol.

Specificity

This antibody recognizes the C-terminal sequence shared by metabotropic glutamate receptors 2 and 3.

Application

Anti-Glutamate Receptor 2/3, Metabotropic (mGluR2/3) antibody produced in rabbit is suitable for immunohistochemistry and indirect immunofluorescence at a working dilution of 1:500. It is suitable for immunoprecipitation at 1:100 and for immunoblotting at 1:1000 working dilution.

Biochem/physiol Actions

GRM2 and GRM3 belong to group II receptors and are involved in the inhibition of the cyclic AMP cascade. The role of the metabotropic receptors in pain and pathology is being studied for therapeutic potential. Glutamate receptors are key regulators of excitatory amino acid neurotransmission in the striatum.

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