Anti-Complement C3 antibody produced in chicken

Immunogen

Complement C3 native protein.

Immunogen Sequence: GI # 4557385, sequence 1-1663

General description

Chicken polyclonal anti-Complement C3 antibody reacts with human complement C3.

Complement C3 plays a central role in the activation of the complement system. It’s processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability, and causes histamine release from mast cells and basophilic leukocytes.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Application

Chicken polyclonal anti-Complement C3 antibody is used to tag complement C3 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as ELISA and western blotting. It is used as a probe to determine the presence and roles of complement C3 as a component of the complement system.