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H0652 Sigma

Anti-Hepatocyte Growth Factor antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym: Anti-HGF

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies for Pancreatic Stem Cells,
species reactivity   human
application(s)   neutralization: suitable
  neutralization: suitable
  western blot: suitable
clone   polyclonal
antibody form   IgG fraction of antiserum
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... HGF(3082)
biological source   goat
conjugate   unconjugated

Description

Immunogen

recombinant human hepatocyte growth factor.

General description

Hepatocyte Growth Factor (HGF) is a multifunctional, heparin-binding factor that stimulates the proliferation of liver cells. The cellular effects of HGF are mediated by its receptor, c-Met, that leads to significant activation of ERK, Src/FAK, STAT3 and PI3K signaling. Cells of mesenchymal origin express HGF that stimulates the c-Met expression via an autocrine loop. Various functions of the HGF/c-Met signaling include proliferation, cell survival, motility and adhesion and tissue regeneration. Apart from liver, HGF also mediates regeneration of kidney, lung and gastro-intestines. It is also important for maintaining the insulin production and prevents hypoglycemia, self-repair of cartilage, muscle and skin and hematopoiesis. The HGF/c-Met signaling is reported as a promising therapeutic target in prevention of angiogenesis in cancer and maintaining synaptic plasticity in Alzheimer’s disease
Monoclonal Anti-Hepatocyte Growth Factor recognizes human HGF.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Preparation Note

Purified by Protein G.

Application

Anti-Hepatocyte Growth Factor antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml is recommended. The antibody is suitable for neutralization reactions. A concentration of 500ng/ml of anti-HGF has been used to neutralize HGF in the conditioned medium of NIH3TS cells. Anti-HGF has been used at a working concentration of 20μg/ml for immunohistochemistry of section of cervical lesions.

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