Hygromycin B solution from Streptomyces hygroscopicus
≥60% (HPAE), 45-60 mg/mL in H2O
DOWNLOAD MSDS (PDF)-
CAS Number 31282-04-9
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Empirical Formula (Hill Notation) C20H37N3O13
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Molecular Weight 527.52
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Beilstein Registry Number 6755837
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MDL number MFCD06795479
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PubChem Substance ID 24895410
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Popular Documents: Product Information Sheet (PDF) | Specification Sheet (PDF)
Properties
| Related Categories | Aminoglycosides, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, |
| sterility | 0.22 μm filtered |
| assay | ≥60% (HPAE) |
| concentration | 45-60 mg/mL in H2O |
| storage temp. | 2-8°C |
Description
Application
Hygromycin has been used to select drug-resistant stable transfectants after transfer of the hygromycin phosphotransferase gene in a variety of cell culture applications.
Hygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus that kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis. It is used for the selection and maintenance of prokaryotic and eukaryotic cells that contain the hygromycin resistance gene. It is used in gene transfer experiments as a selection agent. Product H0654 is a solution that comes ≥60% (HPAE) and 45-60 mg/mL in H2O.
Biochem/physiol Actions
Antibacterial and antifungal. Mode of action: Inhibition of protein synthesis, by inducing the misreading of the m-RNA template in prokaryotes and eukaryotes. It selectively penetrates cells that have been rendered permeable by virus infection.
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