|Related Categories||Antagonists, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cholinergics,|
|mp||282-285 °C (dec.)|
|Gene Information||human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)|
Preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier only at high doses.
Certificate of Analysis
Nicotinic acetylcholine receptors (nAChRs) constitute a family of ligand-gated channels, originally classified on the basis of their activation by the alkaloid nicotine, with acetylcholine (ACh) bein...
Keywords: Analgesics, Diseases, Dopamine agents, Gene expression, Genetic, Inflammation, Ligands, Microscopy, Neurotransmission, Neurotransmitters, Scanning electron microscopy, Schizophrenia, Tissue microarrays, Transduction
Melatonin inhibits alcohol-induced increases in duodenal mucosal permeability in rats in vivo. Sommansson A, Saudi WS, Nylander O, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 305(1), G95-G105, (2013)
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Capillary ion electrophoresis of inorganic anions and uric acid in human saliva using a polyvinyl alcohol coated capillary column and hexamethonium chloride as additive of background electrolyte. Mori M, Yamamoto T, Kaseda M, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 887-888, 1-7, (2012)
Hexamethonium reverses the lethal cardiopulmonary damages in a rat model of brainstem lesions mimicking fatal enterovirus 71 encephalitis. Lu WH, Hsieh KS, Lu PJ, et al. Crit. Care Med. 41(5), 1276-85, (2013)
Adenosine A(2A) receptor antagonists are broad facilitators of antinicotinic neuromuscular blockade monitored either with 2 Hz train-of-four or 50 Hz tetanic stimuli. Pereira MW, Correia-de-Sá P, and Alves-Do-Prado W Clin. Exp. Pharmacol. Physiol. 39(10), 869-77, (2012)
Time-dependent changes in autonomic control of splanchnic vascular resistance and heart rate in ANG II-salt hypertension. Kuroki MT, Guzman PA, Fink GD, et al. Am. J. Physiol. Heart Circ. Physiol. 302(3), H763-9, (2012)
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