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H1142 Sigma

15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid

~150 μg/mL in ethanol, ≥97.0% (HPLC)

Synonym: (15S,5Z,8Z,11Z,13E)-15-Hydroxyeicosatetraenoic acid, (S)-15-HETE, 15(S)-HETE

  • CAS Number 54845-95-3

  • Empirical Formula (Hill Notation) C20H32O3

  • Molecular Weight 320.47

  •  Beilstein Registry Number 2470466

  •  MDL number MFCD00063590

  •  PubChem Substance ID 24895431

  • Popular Documents:  Datasheet (PDF)  

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Properties

Related Categories Arachidonic Acid Cascade, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Fatty Acids and conjugates,
InChI Key   JSFATNQSLKRBCI-VAEKSGALSA-N
assay   ≥97.0% (HPLC)
concentration   ~150 μg/mL in ethanol
shipped in   dry ice
storage temp.   −20°C

Description

Biochem/physiol Actions

Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN1170 - class 3 - PG 2 - Ethanol, solution
WGK Germany 
3
Flash Point(F) 
57.2 °F
Flash Point(C) 
14 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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