Hyperforin (dicyclohexylammonium) salt
DOWNLOAD MSDS (PDF)Synonym: Hyp-DCHA, Hyperforin-DCHA
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CAS Number 238074-03-8
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Empirical Formula (Hill Notation) C35H52O4·C12H23N
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Molecular Weight 718.10
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MDL number MFCD04000098
Properties
| Related Categories | Bioactive Small Molecules, Cell Biology, Glycosides, Including Glucosinolates, H, Nutrition Research, |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | protect from light |
| color | white to off-white |
| solubility | DMSO: ≥10 mg/mL |
| storage temp. | −20°C |
Description
Biochem/physiol Actions
Hyperforin is believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John′s wort. It acts as a reuptake inhibitor of monoamines, including serotonin, norepinephrine, dopamine, and of GABA and glutamate by activating the transient receptor potential ion channel TRPC6. It also is an activator of the pregnane X receptor (PXR), which serves as a key regulator of CYP3A4 transcription, a member of the cytochrome (CYP) P450 enzyme system. Recent studies have found it to have neuroprotective effects against Alzheimer′s disease (AD) neuropathology, including the ability to disassemble amyloid-β aggregates in vitro and improve spatial memory in vivo.1
Stable salt of hyperforin. Hyperforin is believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John′s wort. It acts as a reuptake inhibitor of monoamines, including serotonin, norepinephrine, dopamine, and of GABA and glutamate by activating the transient receptor potential ion channel TRPC6. Activation of TRPC6 induces the entry of sodium and calcium into the cell which causes inhibition of monoamine reuptake. It also is an activator of the pregnane X receptor (PXR), which serves as a key regulator of CYP3A4 transcription, a member of the cytochrome (CYP) P450 enzyme system. Recent studies have found other neurological effects, effects on inflammation, as well as antibacterial, antitumoral and antiangiogenic effects.
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