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H2380 Sigma

6-Hydroxy-DL-DOPA

≥98% (TLC), powder

Synonym: 2,4,5-Trihydroxy-DL-phenylalanine, 2,5-Dihydroxy-DL-tyrosine

  • CAS Number 21373-30-8

  • Empirical Formula (Hill Notation) C9H11NO5

  • Molecular Weight 213.19

  •  Beilstein Registry Number 2860065

  •  MDL number MFCD00004272

  •  PubChem Substance ID 24278464

  • Popular Documents:  FTNMR (PDF)  

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Properties

Related Categories Adrenergics, Cell Biology, Cell Signaling and Neuroscience, Chemical Biology, Chemical Synthesis,
InChI Key   YLKRUSPZOTYMAT-UHFFFAOYSA-N
assay   ≥98% (TLC)
form   powder
color   off-white
solubility   H2O: soluble3 mg/mL (Dissolve in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidant. Solutions should be freshly prepared and protected from exposure to light.)
  1 M HCl: soluble50 mg/mL (Solutions should be freshly prepared and protected from exposure to light.)
storage temp.   −20°C

Description

Caution

Hygroscopic; photosensitive

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Biochem/physiol Actions

6-Hydroxy-DL-DOPA is an inhibitor of APE1 (apurinic/apyrimidinic endonuclease) repair-function activity. APE1 is a nuclease crucial for DNA base excision repair pathway. 6-Hydroxy-DL-DOPA also blocks RAD52 (DNA repair protein) single-stranded DNA binding domain.

Precursor of the catecholaminergic neurotoxin, 6-hydroxydopamine; converted to 6-hydroxydopamine by L-aromatic amino acid decarboxylase.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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