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H3290 Sigma

HIPK1 (156-555), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: KIAA0630, MGC26642, MGC33446, MGC33548, Myak, Nbak2

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Properties

Related Categories Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
recombinant   expressed in baculovirus infected Sf9 cells
grade   PRECISIO® Kinase
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   67-91 nmol/min·mg
mol wt   mol wt ~71 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... HIPK1(204851)

Description

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Biochem/physiol Actions

HIPK1 (homeodomain-interacting protein kinase 1) is responsible for phosphorylation of homeodomain transcription factors. HIPK1 interacts with DAXX (death domain-associated protein 6) and decreases its transcriptional repression activity. It is up-regulated in breast cancer cell lines and is suggested to be involved in tumorigenesis, partly by serine phosphorylation of p53.

General description

HIPK1 (homeodomain-interacting protein kinase 1) is a serine/threonine protein kinase. It belongs to the HIPK family. The protein is present in the nucleus.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
Protocols & Articles
Peer-Reviewed Papers
15

References

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