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H3375 Sigma

HEPES

≥99.5% (titration)

Synonym: 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid, N-(2-Hydroxyethyl)piperazine-N′-(2-ethanesulfonic acid)

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Properties

Related Categories Apoptosis and Cell Cycle, Biochemicals and Reagents, Biological Buffers, Buffers, Buffers A to Z,
Quality Level   ELITE
assay   ≥99.5% (titration)
useful pH range   6.8 - 8.2
pKa (25 °C)   7.5
Featured Industry   Diagnostic Assay Manufacturing

Description

Frequently Asked Questions

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Packaging

1 kg in poly bottle

25, 100, 250, 500 g in poly bottle

5, 25, 50 kg in poly drum

Legal Information

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

Other Notes

Go to Redi-Dri Product Listing RDD002

Protocols & Applications

Ensure correct concentrations of buffer solutions with the Buffer Calculator

Price and Availability


OEM & Contract Manufacturing Services Available

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Safety & Documentation

Safety Information

WGK Germany 
1
RTECS 
TL6809000
Protocols & Articles

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Buffer Reference Center

Citric Acid – Na2HPO4 Buffer Solutions, pH approx. 2.6–7.61 Citric acid monohydrate, C6H8O7 • H2O, M. wt. 210.14; 0.1M-solution contains 21.01 g/l. Na2HPO4, M. wt. 141.98; 0.2M-solution contains 28.4...
Keywords: Biological Buffers, Buffers

Peer-Reviewed Papers

References

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Natural killer T cell activation overcomes immunosuppression to enhance clearance of postsurgical breast cancer metastasis in mice. Gebremeskel S, Clattenburg DR, Slauenwhite D, et al. Oncoimmunology 4(3), e995562, (2015)

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Novel role of hematopoietic stem cells in immunologic rejection of malignant gliomas. Flores C, Pham C, Snyder D, et al. Oncoimmunology 4(3), e994374, (2015)

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Identification and Functional Characterization of P159L Mutation in HNF1B in a Family with Maturity-Onset Diabetes of the Young 5 (MODY5). Kim EK, Lee JS, Cheong HI, et al. Genomics. Inform. 12(4), 240-6, (2015)

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Melanoma cells homing to the brain: an in vitro model. Rizzo A, Vasco C, Girgenti V, et al. Biomed Res. Int. 2015, 476069, (2015)

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Overexpression of C-terminal fragment of glutamate receptor 6 prevents neuronal injury in kainate-induced seizure via disassembly of GluR6-PSD-95-MLK3 signaling module. Mou J, Liu X, Pei D, et al. Neural Regen. Res. 9(23), 2059-65, (2015)

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Adsorption of the inflammatory mediator high-mobility group box 1 by polymers with different charge and porosity. Tripisciano C, Eichhorn T, Harm S, et al. Biomed Res. Int. 2014, 238160, (2014)

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Requirement of dual stimulation by homologous recombinant IL-2 and recombinant IL-12 for the in vitro production of interferon gamma by canine peripheral blood mononuclear cells. Pereira AM, de Pinheiro CG, Dos Santos LR, et al. BMC Res. Notes 7, 460, (2014)

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Genistein induces deleterious effects during its acute exposure in Swiss mice. Singh P, Sharma S, Rath SK, et al. Biomed Res. Int. 2014, 619617, (2014)

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Invasion of endothelial cells and arthritogenic potential of endocarditis-associated Corynebacterium diphtheriae. Peixoto RS, Pereira GA, Sanches dos Santos L, et al. Microbiology 160(Pt 3), 537-46, (2014)

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Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids. Matano M, Date S, Shimokawa M, et al. Nat. Med. 21(3), 256-62, (2015)

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Secreted biomolecules alter the biological identity and cellular interactions of nanoparticles. Albanese A, Walkey CD, Olsen JB, et al. ACS Nano 8(6), 5515-26, (2014)

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Multipotent Stromal Cells Outperform Chondrocytes on Cartilage-Derived Matrix Scaffolds. Benders KE, Boot W, Cokelaere SM, et al. Cartilage. 5(4), 221-30, (2015)

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Autophagy inhibition augments the anticancer effects of epirubicin treatment in anthracycline-sensitive and -resistant triple-negative breast cancer. Chittaranjan S, Bortnik S, Dragowska WH, et al. Clin. Cancer Res. 20(12), 3159-73, (2014)

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Estrogen receptor ? upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer. Dey P, Ström A, Gustafsson JÅ, et al. Oncogene 33(33), 4213-25, (2014)

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Gene-expression profiling elucidates molecular signaling networks that can be therapeutically targeted in vestibular schwannoma. Agnihotri S, Gugel I, Remke M, et al. J. Neurosurg. 121(6), 1434-45, (2014)

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Nebivolol for improving endothelial dysfunction, pulmonary vascular remodeling, and right heart function in pulmonary hypertension. Perros F, Ranchoux B, Izikki M, et al. J. Am. Coll. Cardiol. 65(7), 668-80, (2015)

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Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering. Shiba-Fukushima K, Arano T, Matsumoto G, et al. PLoS Genet. 10(12), e1004861, (2014)

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Distinct APC subtypes drive spatially segregated CD4+ and CD8+ T-cell effector activity during skin infection with HSV-1. Macleod BL, Bedoui S, Hor JL, et al. PLoS Pathog. 10(8), e1004303, (2014)

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Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets. Hall E, Volkov P, Dayeh T, et al. BMC Med. 12, 103, (2014)

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Chondrogenesis of infrapatellar fat pad derived adipose stem cells in 3D printed chitosan scaffold. Ye K, Felimban R, Traianedes K, et al. PLoS ONE 9(6), e99410, (2014)

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C. elegans Punctin specifies cholinergic versus GABAergic identity of postsynaptic domains. Pinan-Lucarré B, Tu H, Pierron M, et al. Nature 511(7510), 466-70, (2014)

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Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease. Cleynen I, Vazeille E, Artieda M, et al. Gut 63(8), 1265-74, (2014)

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Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection. Tzelepis F, Verway M, Daoud J, et al. J. Clin. Invest. 125(2), 752-68, (2015)

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REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury. Morquette B, Morquette P, Agostinone J, et al. Cell Death Differ. 22(4), 612-25, (2015)

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eEF2 and Ras-GAP SH3 domain-binding protein (G3BP1) modulate stress granule assembly during HIV-1 infection. Valiente-Echeverría F, Melnychuk L, Vyboh K, et al. Nat. Commun. 5, 4819, (2014)

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Agonistic CD200R1 DNA Aptamers Are Potent Immunosuppressants That Prolong Allogeneic Skin Graft Survival. Prodeus A, Cydzik M, Abdul-Wahid A, et al. Mol. Ther. Nucleic Acids 3, e190, (2014)

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Biomechanical strain as a trigger for pore formation in Schlemm's canal endothelial cells. Braakman ST, Pedrigi RM, Read AT, et al. Exp. Eye Res. 127, 224-35, (2014)

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Revisiting the arthritogenic peptide theory: quantitative not qualitative changes in the peptide repertoire of HLA-B27 allotypes. Schittenhelm RB, Sian TC, Wilmann PG, et al. Arthritis Rheumatology 67(3), 702-13, (2015)

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Protrusion force microscopy reveals oscillatory force generation and mechanosensing activity of human macrophage podosomes. Labernadie A, Bouissou A, Delobelle P, et al. Nat. Commun. 5, 5343, (2014)

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HepaRG cells as human-relevant in vitro model to study the effects of inflammatory stimuli on cytochrome P450 isoenzymes. Rubin K, Janefeldt A, Andersson L, et al. Drug Metab. Dispos. 43(1), 119-25, (2014)

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New structural insights into the apelin receptor: identification of key residues for apelin binding. Gerbier R, Leroux V, Couvineau P, et al. FASEB J. 29(1), 314-22, (2015)

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Methoprene-tolerant (Met) knockdown in the adult female cockroach, Diploptera punctata completely inhibits ovarian development. Marchal E, Hult EF, Huang J, et al. PLoS ONE 9(9), e106737, (2014)

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Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGF?/activin signaling pathway. Whitworth DJ, Frith JE, Frith TJ, et al. Stem Cells Dev. 23(24), 3021-33, (2014)

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Structural evaluation of tandem hairpin pyrrole-imidazole polyamides recognizing human telomeres. Hirata A, Nokihara K, Kawamoto Y, et al. J. Am. Chem. Soc. 136(32), 11546-54, (2014)

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Benzodiazepine ligands rapidly influence GABAA receptor diffusion and clustering at hippocampal inhibitory synapses. Lévi S, Le Roux N, Eugène E, et al. Neuropharmacology 88, 199-208, (2014)

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Genome-wide small interfering RNA screens reveal VAMP3 as a novel host factor required for Uukuniemi virus late penetration. Meier R, Franceschini A, Horvath P, et al. J. Virol. 88(15), 8565-78, (2014)

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TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer. Busch S, Acar A, Magnusson Y, et al. Oncogene 34(1), 27-38, (2015)

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Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines. Caccamo N, Pietra G, Sullivan LC, et al. Eur. J. Immunol. 45(4), 1069-81, (2015)

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BRF1 mutations alter RNA polymerase III-dependent transcription and cause neurodevelopmental anomalies. Borck G, Hög F, Dentici ML, et al. Genome Res. 25(2), 155-66, (2015)

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The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity. Hoffmann FS, Kuhn PH, Laurent SA, et al. J. Immunol. 194(2), 542-52, (2015)

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Stretch-induced human myometrial cytokines enhance immune cell recruitment via endothelial activation. Lee YH, Shynlova O, Lye SJ, et al. Cell. Mol. Immunol. 12(2), 231-42, (2015)

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Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation. Bald T, Landsberg J, Lopez-Ramos D, et al. Cancer Discov. 4(6), 674-87, (2014)

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Combination of immortalization and inducible death strategies to generate a human mesenchymal stromal cell line with controlled survival. Bourgine P, Le Magnen C, Pigeot S, et al. Stem Cell Res. 12(2), 584-98, (2014)

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The ATP-mediated formation of the YgjD-YeaZ-YjeE complex is required for the biosynthesis of tRNA t6A in Escherichia coli. Zhang W, Collinet B, Perrochia L, et al. Nucleic Acids Res. 43(3), 1804-17, (2015)

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Prospective heterotopic ossification progenitors in adult human skeletal muscle. Downey J, Lauzier D, Kloen P, et al. Bone 71, 164-70, (2014)

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A novel flow cytometric method to assess inflammasome formation. Sester DP, Thygesen SJ, Sagulenko V, et al. J. Immunol. 194(1), 455-62, (2014)

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Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity. Jaworski M, Marsland BJ, Gehrig J, et al. EMBO J. 33(23), 2765-81, (2014)

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Autocrine signaling is a key regulatory element during osteoclastogenesis. Kopesky P, Tiedemann K, Alkekhia D, et al. Biol. Open 3(8), 767-76, (2014)

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Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway. Hansen K, Prabakaran T, Laustsen A, et al. EMBO J. 33(15), 1654-66, (2014)

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MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale. Du NH, Arpat AB, De Matos M, et al. Elife 3, e02510, (2014)

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Merck 14,4654

Beil. 23,V,2,379

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