|Related Categories||Androgen, Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones,|
|color||white to tan|
|solubility||DMSO: >10 mg/mL|
|storage temp.||room temp|
Hydroxflutamide is an AR antagonist. Androgen receptors (ARs) are nuclear hormone receptors/transcription factors. Hydroxyflutamide is an androgen antagonist with publications going back to 1981. It is one of a few gold standard AR antagonists; activities of new antagonists are measured against hydroxyflutamide.
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Suppression of androgen receptor enhances the self-renewal of mesenchymal stem cells through elevated expression of EGFR. Huang CK, Tsai MY, Luo J, et al. Biochim. Biophys. Acta 1833(5), 1222-34, (2013)
Fluorescence lifetime imaging microscopy for the monitoring of green fluorescent protein-tagged androgen receptors in living cells. Miyake R, Uchimura T, Li X, et al. Chem. Pharm. Bull. 61(1), 82-4, (2013)
Effects of testosterone and 2-hydroxyflutamide on progesterone receptor expression in porcine ovarian follicles in vitro. Duda M, Durlej-Grzesiak M, Tabarowski Z, et al. Reprod. Biol. 12(4), 333-40, (2012)
Administration of flutamide alters sperm ultrastructure, sperm plasma membrane integrity and its stability, and sperm mitochondrial oxidative capability in the boar: in vivo and in vitro approach. Lydka M, Piasecka M, Gaczarzewicz D, et al. Reprod. Domest. Anim. 47(4), 635-43, (2012)
Androgen receptors in the posterior bed nucleus of the stria terminalis increase neuropeptide expression and the stress-induced activation of the paraventricular nucleus of the hypothalamus. Bingham B, Myung C, Innala L, et al. Biol. Psychiatry 36(7), 1433-43, (2011)
Determination of 2-hydroxyflutamide in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS): application to a bioequivalence study on Chinese volunteers. Zheng H, Wu D, Qian ZY, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878(19), 1611-5, (2010)
Systematic structure-function analysis of androgen receptor Leu701 mutants explains the properties of the prostate cancer mutant L701H. van de Wijngaart DJ, Molier M, Lusher SJ, et al. J. Biol. Chem. 285(7), 5097-105, (2010)
Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and Its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips. Choucha Snouber L, Bunescu A, Naudot M, et al. Toxicol. Sci. 132(1), 8-20, (2013)
Androgen receptor signals regulate UDP-glucuronosyltransferases in the urinary bladder: a potential mechanism of androgen-induced bladder carcinogenesis. Izumi K, Zheng Y, Hsu JW, et al. Mol. Carcinog. 52(2), 94-102, (2013)
Androgen receptor coregulators NOCR1, TIF2, and ARA70 may account for the hydroxyflutamide insensitivity of prostate cancer cells. Wang Y, Li JQ, Shao C, et al. Ir. J. Med. Sci. 180(4), 865-72, (2011)
Hydroxyflutamide enhances cellular sensitivity to 5-fluorouracil by suppressing thymidylate synthase expression in bicalutamide-resistant human prostate cancer cells. Kawabata R, Oie S, Oka T, et al. Int. J. Oncol. 38(3), 665-76, (2011)
Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites. Kostrubsky SE, Strom SC, Ellis E, et al. Chem. Res. Toxicol. 20(10), 1503-12, (2007)
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