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H4637 Sigma

4-Hydroxyestradiol

Synonym: 1,3,5(10)-Estratriene-3,4,17β-triol

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Properties

InChI Key   QOZFCKXEVSGWGS-ZHIYBZGJSA-N
storage temp.   −20°C
Gene Information   human ... ESR1(2099)
rat ... Ar(24208)

Description

Packaging

1, 5, 10 mg in glass insert

Biochem/physiol Actions

4-Hydroxyestradiol, an metabolite of estradiol, forms adducts with adenine (N3) and guanine (N7) by depurinating sites in DNA of cultured human breast epithelial cells. This effect may play an important role in malignant transformation of these cells.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H4637.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

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Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
KG7676000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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