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H5534 Sigma

trans-4-Hydroxy-L-proline

BioReagent, suitable for cell culture, ≥98.5%

Synonym: (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, 4-Hydroxyproline, Hydroxyproline, Hyp

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Description

Other Notes

Natural constituent of animal structural proteins such as collagen and elastin.

Packaging

1 kg in poly bottle

10 mg in autosample vial

25, 100 g in poly bottle

Biochem/physiol Actions

Hydroxyproline (4-hydroxyproline) is a non-proteinogenic amino acid formed by the post-translational hydroxylation of proline. Hydroxyproline is a major component of collagen, where it serves to stabilize the helical structure. Because hydroxyproline is largely restricted to collagen, the measurement of hydroxylproline levels can be used as an indicator of collagen content. Conditions that increase collagen turnover can elevate serum and urine hydroxyproline levels. Urine and serum hydroxyproline levels can be used as a marker for bone resorption.

Trans-4-Hydroxy-L-proline is a chiral compound used in the synthesis of depsilairdin analogues; hydroxymethyl-2-pyrrolidinone (5) nucleoside analogs; enantiomerically pure polyheterocyclic spiro-β-lactams and the ABC-ring system of the antitumor antibiotic MPC1001.

Price and Availability


Filter out uncertainty.

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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