H6027 Sigma

Histatin 5

≥97% (HPLC)

  • CAS Number 104339-66-4

  • Empirical Formula (Hill Notation) C133H195N51O33

  • Molecular Weight 3036.29

  •  MDL number MFCD00210682

Description

Amino Acid Sequence

Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr

Biochem/physiol Actions

A human salivary peptide that inhibits the protease of Bacteroides gingivalis, as well as clostripain.

The antifungal (Candida, Leishmania) activity of histatin 5 involves penetration of the microbial cell, localization in the mitochondria, and inhibition of F1-F0 ATPase, with rapid depletion of ATP.1

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