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H6285 Sigma

High Throughput Screening: The Discovery of Bioactive Substances

  •  ISBN-10 0-8247-0067-8

  •  ISBN-13 978-0-8247-0067-6

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Related Categories Biochemicals and Reagents, Books and Software, Complex Carbohydrate Analysis, Drug Discovery Books, Enzymes, Inhibitors, and Substrates,
publication info   J.P. Devlin, ed., Marcel Dekker, 1997, 704 pp., hard cover
mfr. no.   Marcel Dekker

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General description

Furnishing information on the most important investigational system for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this resource facilitates the transition from classical to high throughput screening (HTS) systems and provides a foundation for the implementation and development of HTS in bio-based industries and associated academic environments. Topics include how to attain natural products for HTS programs.

Table of Contents

Natural Products as a Discovery Resource, edited by John P. Devlin
Chemical Diversity and Genetic Equity: Synthetic and Naturally Derived Compounds,
John P. Devlin
Microcollection of Plants for Biochemical Profiling, John P. Devlin
Enzymes and Microbes as a Source of Chemical Diversity, Saul L. Neidleman
The Marine Environment as a Discovery Resource, Gregg R. Dietzman
Compound Sourcing: Chemically Generated Screening Libraries, edited by Michael R. Pavia
Introduction, Michael R. Pavia
Rapidly Expanding Molecular Diversity: Libraries from Libraries,
John S. Kiely, Barbara Drner, John M. Ostresh, Colette Dooley, and Richard A. Houghten
Synthesis of Encoded Small Molecule Combinatorial Libraries via ECLiPS, Jack J. Baldwin and Ian Henderson
Parallel Organic Synthesis Using Parke-Davis′ Diversomer(r) Method, Sheila Hobbs DeWitt and Anthony W. Czarnik
Rapid Discovery and Optimization of Biologically Active Small Molecules Using Automated Synthesis Methods, Adnan M. M. Mjalli and Barry E. Toyonaga

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