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H6891 Sigma

7β-Hydroxycholesterol

≥95%

Synonym: 5-Cholestene-3β,7β-diol

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Properties

Related Categories Anti-Proliferative Agents, Antitumor Agents, Biochemicals and Reagents, Cancer Research, Cell Biology,
InChI Key   OYXZMSRRJOYLLO-UHFFFAOYSA-N
assay   ≥95%

Description

Packaging

1, 5 mg in glass bottle

10 mg in poly bottle

Preparation Note

7β-Hydroxycholesterol yields clear, colorless to faint yellow solution in ethanol, with or without heating.

Application

7β-hydroxycholesterol was used to study oxysterol-induced apoptosis in human endothelial cells.

Biochem/physiol Actions

7β-Hydroxycholesterol is an oxysterol, the enzymatic or non-enzymatic product of cholesterol oxidation. Oxysterols are cytotoxic and induce death in monocytes, smooth muscle cells and endothelial cells. The mechanism of apoptosis induced by oxysterols may involve caspases or DNA fragmentation. Increased levels of 7β-Hydroxycholesterol correlates with increased risk of cardiovascular diseases including atherosclerosis.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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