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H7379 Sigma

Hemoglobin human

lyophilized powder

Synonym: Hb

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
form   lyophilized powder
impurities   HIV and hepatitis B antigen, tested negative
solubility   H2O: soluble 20 mg/mL
storage temp.   2-8°C
Gene Information   human ... HBA1(3039), HBA2(3040), HBB(3043), HBD(3045), HBE1(3046), HBG1(3047), HBG2(3048), HBQ1(3049), HBZ(3050)

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Biochem/physiol Actions

Oxygen transporter, NO scavenger

The Fe2+/Fe3+ balance is a physiological indicator of blood oxygenation. Deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues.

Caution

Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin.

Packaging

1, 5, 10 g in poly bottle

Application

Hemoglobin was used in the development of a rapid enzyme immunoassay for the detection of retinol-binding protein. It was also used in the inhibition of human platelet reactivity by endothelium-derived relaxing factor.

General description

Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.

Price and Availability


All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
Is Product H7379, Hemoglobin human, methemoglobin?
Yes. The iron in hemoglobin will oxidize by exposure to air unless special handling and packaging is used.  Because this product is exposed to air during purification and packaging, it will be predominantly methemoglobin.
How can Product H7379, Hemoglobin human, be reduced?
A procedure for reduction of methemoglobin may be found in the product sheet posted on the Sigma-Aldrich website:  http://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma/Product_Information_Sheet/2/h7379pis.pdf
How many donors are used to make a batch of Product H7379, Hemoglobin human?
This will vary with the batch size, but may come from as many as several hundred donors. All donors are tested and found negative for antibodies to HIV-1/HIV-2, HCV, for HBSAG, and for syphilis.
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
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Protocols & Articles

Articles

Cellular Derived Blood Proteins and Enzymes

Cell damage is induced by reactive oxygen species (ROS). ROS are either free radicals, reactive anions containing oxygen atoms, or molecules containing oxygen atoms that can either produce free radic...
BioFiles 2006, 1.5, 4.
Keywords: Aerobic, Alzheimer Disease, Bacterial conjugations, Biofiles, Cancer, Metabolism, Oxidations, Parkinson Disease, Reductions, Respiration

HPLC Analysis of Hemoglobin HbA1C on Mono S® HR5/5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Hemoglobin HbA1C on Mono S® HR5/5
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Hemoglobin S on Discovery® BIO PolyMA-SCX, Ion Exchange

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Hemoglobin S on Discovery® BIO PolyMA-SCX, Ion Exchange
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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