(Z)-4-Hydroxytamoxifen

Papers

Structure-function relationships of hydroxylated metabolites of tamoxifen that control the proliferation of estrogen-responsive T47D breast cancer cells in vitro Murphy CS, et al. Mol. Pharmacol. 38, 737-743, (1990)

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Activation of the p38 mitogen-activated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen receptor-induced apoptosis Zhang CC, and Shapiro DJ. J. Biol. Chem. 275, 479-486, (2000)

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Estrogen receptor-dependent and estrogen receptor-independent pathways for tamoxifen and 4-hydroxytamoxifen-induced programmed cell death Obrero M, et al. J. Biol. Chem. 277, 45695-45703, (2002)

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Effect of prolonged hydroxytamoxifen treatment of MCF-7 cells on mitogen activated kinase cascade Rabenoelina F, et al. Int. J. Cancer 98, 698-706, (2002)

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Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death Zhou JH, et al. Steroids 72, 765-777, (2007)

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An autocrine VEGF/VEGFR2 and p38 signaling loop confers resistance to 4-hydroxytamoxifen in MCF-7 breast cancer cells Aesoy R, et al. Mol. Cancer Res. 6, 1630-1638, (2008)

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Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation Kandilci, A., and Grosveld, G.C. Blood 114, 1596-606, (2009)

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Aurora-A Kinase Is Essential For Bipolar Spindle Formation And Early Development. Cowley, D.O., et al. Mol. Cell. Biol. 29, 1059-71, (2009)

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A Feedback Loop Involving The Phd3 Prolyl Hydroxylase Tunes The Mammalian Hypoxic Response In Vivo. Minamishima, Y.A., et al. Mol. Cell. Biol. 29, 5729-41, (2009)

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Temporally-controlled Site-specific Recombination In Zebrafish. Hans, S., et al. PLoS ONE 4, e4640, (2009)

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Absence Of Glutathione Peroxidase 4 Affects Tumor Angiogenesis Through Increased 12/15-lipoxygenase Activity. Schneider, M., et al. Neoplasia 12, 254-63, (2010)

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12/15-lipoxygenase-derived Lipid Peroxides Control Receptor Tyrosine Kinase Signaling Through Oxidation Of Protein Tyrosine Phosphatases. Conrad, M., et al. Proc. Natl. Acad. Sci. U. S. A. 107, 15774-9, (2010)

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Potent Inhibition Of Rhabdoid Tumor Cells By Combination Of Flavopiridol And 4OH-tamoxifen. Cimica, V., et al. BMC Cancer 10, 634, (2010)

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Ubiquitous Transgene Expression And Cre-based Recombination Driven By The Ubiquitin Promoter In Zebrafish. Mosimann, C., et al. Development 138, 169-77, (2011)

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Removal of shelterin reveals the telomere end-protection problem. Sfeir, A. and de Lange, T. Science 336, 593-7, (2012)

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Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling. William J Hoekstra et al J. Med. Chem. 48, 2243-7, (2005)

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Selective estrogen receptor modulators in the ruthenocene series. Synthesis and biological behavior. Pascal Pigeon et al J. Med. Chem. 48, 2814-21, (2005)

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Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. Zuercher WJ., et al. J. Med. Chem. 48, 3107-3109, (2005)

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Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. Markus A Lill et al J. Med. Chem. 48, 5666-74, (2005)

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Differential response of estrogen receptor subtypes to 1,3-diarylindene and 2,3-diarylindene ligands. Nicola J Clegg et al J. Med. Chem. 48, 5989-6003, (2005)

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Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Esther Y H Chao et al Bioorg. Med. Chem. Lett. 16, 821-4, (2006)

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Isoflavonoids with antiestrogenic activity from Millettia pachycarpa. Chihiro Ito et al J. Nat. Prod. 69, 138-41, (2006)

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Virtual and biomolecular screening converge on a selective agonist for GPR30. Cristian G Bologa et al Nat. Chem. Biol. 2, 207-12, (2006)

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Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators. Irene Barrett et al Bioorg. Med. Chem. 16, 9554-73, (2008)

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Synthesis and preliminary biological evaluation of new carbon-11 labeled tetrahydroisoquinoline derivatives as SERM radioligands for PET imaging of ER expression in breast cancer. Mingzhang Gao et al Eur. J. Med. Chem. 43, 2211-9, (2008)

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Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. Edith Bellavance et al J. Med. Chem. 52, 7488-502, (2009)

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Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Scott, SA., et al Nat. Chem. Biol. 2, 108-117, (2009)

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Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells. Quan Jiang et al J. Med. Chem. 53, 6153-63, (2010)

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2-phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: synthesis and pharmacological evaluation. Sandra Dettmann et al Bioorg. Med. Chem. 18, 4905-16, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Locating the binding sites of anticancer tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen on bovine serum albumin. P Bourassa et al Eur. J. Med. Chem. 46, 4344-53, (2011)

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