|Related Categories||Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,|
|protect from light|
|solubility||methanol: soluble10 mg/mL|
|ethanol: soluble20 mg/mL (with heating)|
human ... ESR1(2099), ESR2(2100), ESRRG(2104), IL6(3569)|
rat ... Ar(24208), Esr1(24890), Esr2(25149)
4-Hydroxytamoxifen is the active metabolite of tamoxifen which binds estrogen receptors (ER) and estrogen-related receptors (ERR) with estrogenic and anti-estrogenic effects. It is a selective estrogen receptor modulator (SERM).
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H7904.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Certificate of Analysis
Certificate of Origin
|Personal Protective Equipment||Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||63-20/21/22|
|Safety Statements (Europe)||22-23-36|
Intracellular receptors (IRs) are a class of ligand-dependent transcription factors that include receptors for both steroid and non-steroid hormones. Upon binding their cognate hormone, these recepto...
Keywords: Anti-inflammatory agents, Apoptosis, Atomic absorption spectroscopy, Cancer, Cardiovascular, Cell proliferation, Diseases, Diuretics, Gene expression, Hormones, Infrared spectroscopy, Ligands, Metabolism, Metabolites, Transcription, Transduction
Structure-function relationships of hydroxylated metabolites of tamoxifen that control the proliferation of estrogen-responsive T47D breast cancer cells in vitro Murphy CS, et al. Mol. Pharmacol. 38, 737-743, (1990)
Activation of the p38 mitogen-activated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen receptor-induced apoptosis Zhang CC, and Shapiro DJ. J. Biol. Chem. 275, 479-486, (2000)
12/15-lipoxygenase-derived Lipid Peroxides Control Receptor Tyrosine Kinase Signaling Through Oxidation Of Protein Tyrosine Phosphatases. Conrad, M., et al. Proc. Natl. Acad. Sci. U. S. A. 107, 15774-9, (2010)
Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. Zuercher WJ., et al. J. Med. Chem. 48, 3107-3109, (2005)
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. Markus A Lill et al J. Med. Chem. 48, 5666-74, (2005)
Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators. Irene Barrett et al Bioorg. Med. Chem. 16, 9554-73, (2008)
Synthesis and preliminary biological evaluation of new carbon-11 labeled tetrahydroisoquinoline derivatives as SERM radioligands for PET imaging of ER expression in breast cancer. Mingzhang Gao et al Eur. J. Med. Chem. 43, 2211-9, (2008)
Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. Edith Bellavance et al J. Med. Chem. 52, 7488-502, (2009)
2-phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: synthesis and pharmacological evaluation. Sandra Dettmann et al Bioorg. Med. Chem. 18, 4905-16, (2010)
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