|Related Categories||Bioactive Small Molecules, Cannabinoids, Cell Biology, Cell Signaling and Neuroscience, H,|
|form||solid (air sensitive)|
|drug control||USDEA Schedule I; stupéfiant; regulated under CDSA - not available from Sigma-Aldrich Canada|
|shipped in||wet ice|
human ... CNR1(1268), CNR2(1269)|
rat ... Cnr1(25248)
Cannabinoid receptor agonist.
Certificate of Analysis
Cannabinoid receptors derive their name from Δ9-tetrahydrocannabinol (Δ9-THC), the psychoactive principle in Cannabis sativa (marijuana). Although marijuana has been in use for over 4,000 years as a ...
Keywords: AGE, Atomic absorption spectroscopy, Endocannabinoids, Gene expression, Infrared spectroscopy, Ligands, Metabolism, Neurotransmitters, Transduction
Characterization of the acute endocrine actions of (-)-11-hydroxy-delta8-tetrahydrocannabinol-dimethylheptyl (HU-210), a potent synthetic cannabinoid in rats. Martin-Calderon, J.L. et al. Eur. J. Pharmacol. 344, 77-86, (1998)
[Mediated role of NO-syntase, protein kinase C and KATP-channels in realization of cardioprotective impact of cannabinoid HU-210]. Maslov LN, Lasukova OV, Krylatov AV, et al. Eksp. Klin. Farmakol. 75(12), 15-8, (2012)
Chronic endocannabinoid system stimulation induces muscle macrophage and lipid accumulation in type 2 diabetic mice independently of metabolic endotoxaemia. Geurts L, Muccioli GG, Delzenne NM, et al. PLoS ONE 8(2), e55963, (2013)
Activation of cannabinoid receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms. Michler T, Storr M, Kramer J, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 304(2), G181-92, (2013)
The periaqueductal gray contributes to bidirectional enhancement of antinociception between morphine and cannabinoids. Wilson-Poe AR, Pocius E, Herschbach M, et al. Pharmacol. Biochem. Behav. 103(3), 444-9, (2013)
Prediction of outcome after moderate and severe traumatic brain injury: external validation of the International Mission on Prognosis and Analysis of Clinical Trials (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models. Roozenbeek B, Lingsma HF, Lecky FE, et al. Crit. Care Med. 40(5), 1609-17, (2012)
Cannabinoids prevent lipopolysaccharide-induced neurodegeneration in the rat substantia nigra in vivo through inhibition of microglial activation and NADPH oxidase. Chung ES, Bok E, Chung YC, et al. Brain Res. 1451, 110-6, (2012)
Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo. Bosier B, Muccioli GG, Mertens B, et al. Neuropharmacology 62(7), 2328-36, (2012)
Differential treatment regimen-related effects of HU210 on CB(1) and D(2)-like receptor functionality in the rat basal ganglia. Nguyen VH, Wang H, Verdurand M, et al. Pharmacology 89(1-2), 64-73, (2012)
Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington's disease. Chiodi V, Uchigashima M, Beggiato S, et al. Neurobiol. Dis. 45(3), 983-91, (2012)
Increased brain metabolism after acute administration of the synthetic cannabinoid HU210: a small animal PET imaging study with 18F-FDG. Nguyen VH, Verdurand M, Dedeurwaerdere S, et al. Brain Res. Bull. 87(2-3), 172-9, (2012)
Cannabinoid receptor type 1 protects nigrostriatal dopaminergic neurons against MPTP neurotoxicity by inhibiting microglial activation. Chung YC, Bok E, Huh SH, et al. J. Immunol. 187(12), 6508-17, (2011)
Loss of striatal cannabinoid CB1 receptor function in attention-deficit / hyperactivity disorder mice with point-mutation of the dopamine transporter. Castelli M, Federici M, Rossi S, et al. Eur. J. Neurosci. 34(9), 1369-77, (2011)
Identification of essential cannabinoid-binding domains: structural insights into early dynamic events in receptor activation. Shim JY, Bertalovitz AC, and Kendall DA J. Biol. Chem. 286(38), 33422-35, (2011)
Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of rapamycin (mTOR) pathways. Gomez O, Sanchez-Rodriguez A, Le M, et al. Br. J. Pharmacol. 163(7), 1520-32, (2011)
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