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H8017 Sigma

Hydroxocobalamin acetate

vitamin B12 analog

Synonym: Vitamin B12a acetate

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Properties

Related Categories Biochemicals and Reagents, Vitamin B, Vitamin B12, Vitamins
InChI Key   QHSPIHUMLGFPKX-WYVZQNDMSA-K
storage temp.   2-8°C

Description

Packaging

1 g in glass bottle

250 mg in glass bottle

Biochem/physiol Actions

Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms. Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methylmalonylcoenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate limiting step in the synthesis of methionine.

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Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
GG3740000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Related Content

Vitamin B12, cobalamin, in Cell Culture

Importance and uses of Vitamin B12 in serum-free eucaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell cultures
Keywords: Apoptosis, Cell culture, Cell proliferation, Chemical reactions, Culture media, Degradations, Gene expression, Genetic, Ligands, Mass spectrometry, Metabolism, Methylations, Oxidations, PAGE, Phosphorylations, Redox Reactions, Reductions, Vitamins

Peer-Reviewed Papers
15

References

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08168 Timestrip Plus 8 °C

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