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H8035 Sigma

Heat Shock Protein 47 from rat

≥90% (SDS-PAGE), recombinant, expressed in E. coli, aqueous glycerol solution

Synonym: HSP 47

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
recombinant   expressed in E. coli
assay   ≥90% (SDS-PAGE)
form   aqueous glycerol solution
concentration   ≥0.6 mg protein/mL
shipped in   dry ice
storage temp.   −70°C
Gene Information   rat ... Serpinh1(29345)

Description

Physical form

Solution in 30 mM Tris (pH 8.0), 100 mM NaCl, 1 mM DTT and 0.4 M arginine

Biochem/physiol Actions

Upregulation of Hsp47 (heat shock protein 47) protects cells from high temperatures, heavy metals and oxidative stress. It might also promote wound healing by controlling collagen generation and release. Hsp47 is involved in the folding and stabilization of triple-helical procollagen. Human HSP47 is associated with the pathogenesis of chronic renal fibrosis. In rats, it also participates in the progression of peritoneal fibrosis.

General description

Hsp47 (heat shock protein 47), which is also to referred as serpinh-1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1), is a collagen-binding glycoprotein. It is present in the endoplasmic reticulum and is induced in the presence of cytosolic stress. Hsp47 is from the serine protease inhibitor (serpin) superfamily.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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