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H8158 Sigma

Heat Shock Protein 27 human

recombinant, expressed in E. coli, buffered aqueous solution

Synonym: HSP 27

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
recombinant   expressed in E. coli
assay   ~90% (SDS-GE)
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... HSPB1(3315)

Description

Physical form

Solution in 20 mM Tris HCl, pH 7.5, 10 mM NaCl, 1 mM EDTA, 1 mM DTT

Biochem/physiol Actions

Heat shock proteins (HSPs) are molecular chaperones. They prevent aggregation of unfolded proteins. HSP27 is involved in anti-apoptosis and actin, and microtubule stabilization. It exists in unphosphorylated inactive form and phosphorylated active form. In monocytes, phosphorylated HSP27 is associated with bone mineral density and can contribute to the pathogenesis of osteoporosis. It also participates in iron metabolism and negatively regulates ferroptosis-associated cancer cell death.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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