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H8627 Sigma

Hydroxyurea

98%, powder

Synonym: Hydroxycarbamide

Properties

Related Categories Antitumor Agents, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cancer Research, Cell Biology,
assay   98%
form   powder
color   white
solubility   H2O: soluble50 mg/mL
storage temp.   2-8°C
Gene Information   human ... CA1(759), CA2(760), CYP1A2(1544), RRM1(6240)

Description

Packaging

1, 5, 10, 25, 100 g in poly bottle

Biochem/physiol Actions

Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.

Price and Availability

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