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H8909 Sigma

HBcAg core human

~1 mg/mL, ≥95% (SDS-PAGE), recombinant, expressed in E. coli

Synonym: Hepatitis B virus core antigen

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Properties

Related Categories AIDS and Viral Research Reagents, Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood, Immune System Regulation More...
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
mol wt   mol wt 18 kDa
concentration   ~1 mg/mL
storage temp.   −20°C
Gene Information   hepatitis B virus ... HBVgp4(944568)
human ... HBVgp4(944568)

Description

General description

amino acids 1-183 of HBV core antigen.

Physical form

Solution in 50% glycerol, 7.5 mM phosphate buffer, pH 7.2, 75 mM NaCl.

Biochem/physiol Actions

Positive control for human HBV antibodies.In humans with chronic HBV (hepatitis B virus) infection, cytotoxic effects of blood T lymphocytes can be suppressed by incubating cells with antibodies against hepatitis B core antigen (HBcAg). The antigen can also work as a T-cell independent antigen in athymic mice. However, it is an efficient immunogen, resulting in T-cell activation and increased anti-HBc levels. High cytoplasmic/membranous expression of HBcAg is associated with increased liver inflammation.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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