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H8910 Sigma

Heat Shock Cognate 70-interacting Protein from rat

≥70% (SDS-PAGE), recombinant, expressed in E. coli

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
recombinant   expressed in E. coli
assay   ≥70% (SDS-PAGE)
form   buffered aqueous solution
concentration   1.1 mg protein/mL
shipped in   dry ice
storage temp.   −70°C
Gene Information   rat ... Hspa8*(117125)

Description

Physical form

Solution in 20 mM MOPS, pH 7.2, 50 mM KCl, and 2 mM MgCl2

Biochem/physiol Actions

Hsc70 (heat shock cognate 70) is a molecular chaperone and constitutively expressed type of Hsp70 (heat shock protein 70). It participates in synaptic signal transduction. In hippocampal neurons, it can interact with NFκB (nuclear factor κB) p65. In presence of oxidative stress, it shows protective effect on cardiomyocytes, partly via association with α-enolase. Hsp70 and Hsc70 together are involved in the production and degradation of ERAD (endoplasmic reticulum-associated degradation) substrates. Hsc70 is also needed for myofibril structure maintenance and the suppression of myofibrillar degeneration in presence of mechanical stress.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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