|Related Categories||Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, GlaxoSmithKline,|
|color||white to off-white|
|solubility||DMSO: >10 mg/mL|
Halofantrine is a blocker of delayed rectifier potassium current via the inhibition of hERG channel.
Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria. Klein K, Aarons L, Ter Kuile FO, et al. J. Pharm. Pharmacol. 64(11), 1603-13, (2012)
Distribution of drug resistance genotypes in Plasmodium falciparum in an area of limited parasite diversity in Saudi Arabia. Bin Dajem SM, Al-Farsi HM, Al-Hashami ZS, et al. Am. J. Trop. Med. Hyg. 86(5), 782-8, (2012)
Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease. Chavali AK, Blazier AS, Tlaxca JL, et al. BMC Syst. Biol. 6, 27, (2012)
In vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Côte d'Ivoire). Yavo W, Bla KB, Djaman AJ, et al. Afr. Health Sci. 10(2), 111-6, (2010)
Effects of anti-malarial drugs on the electrocardiographic QT interval modelled in the isolated perfused guinea pig heart system. Kinoshita A, Yamada H, Kotaki H, et al. Malaria Journal 9, 318, (2010)
Effects of polysorbate 80 on the in-vitro precipitation and oral bioavailability of halofantrine from polyethylene glycol 400 formulations in rats. Tønsberg H, Holm R, Bisgaard J, et al. J. Pharm. Pharmacol. 62(1), 63-70, (2010)
Intravenous dosing conditions may affect systemic clearance for highly lipophilic drugs: implications for lymphatic transport and absolute bioavailability studies. Caliph SM, Trevaskis NL, Charman WN, et al. J. Pharm. Sci. 101(9), 3540-6, (2012)
Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana. Legrand E, Yrinesi J, Ekala MT, et al. Antimicrob. Agents Chemother. 56(3), 1382-9, (2012)
Acute hypertriglyceridemia promotes intestinal lymphatic lipid and drug transport: a positive feedback mechanism in lipid and drug absorption. Trevaskis NL, Charman WN, and Porter CJ Mol. Pharm. 8(4), 1132-9, (2011)
Effect of bile on the oral absorption of halofantrine in polyethylene glycol 400 and polysorbate 80 formulations dosed to bile duct cannulated rats. Tønsberg H, Holm R, Mu H, et al. J. Pharm. Pharmacol. 63(6), 817-24, (2011)
Measurement of lumefantrine and its metabolite in plasma by high performance liquid chromatography with ultraviolet detection. Khalil IF, Abildrup U, Alifrangis LH, et al. J. Pharm. Biomed. Anal. 54(1), 168-72, (2011)
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