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H9415 Sigma

5HPP-33

≥98% (HPLC), solid

Synonym: 2-[2,6-bis(1-Methylethyl)phenyl]-5-hydroxy-1H-isoindole-1,3(2H)-dione, 5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione

  • CAS Number 105624-86-0

  • Empirical Formula (Hill Notation) C20H21NO3

  • Molecular Weight 323.39

  •  MDL number MFCD03085294

Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, Microtubule Inhibitors
assay   ≥98% (HPLC)
form   solid
color   white to off-white
solubility   DMSO: >20 mg/mL
storage temp.   2-8°C

Description

Biochem/physiol Actions

5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM).

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