|Related Categories||Cell Biology, Glycosides, Including Glucosinolates, Nutrition Research, Phytochemicals by Chemical Classification, Phytochemicals in Herbal Medicine or Traditional Chinese Medicine (TCM) More...|
One of the major bioactive constituents of St. John′s wort (Hypericum perforatum). Implicated in the antidepressant efficacy of St. John′s wort.1
Traditional Chinese Medicine (TCM) is a healing art that has been practiced for thousands of years. The practice of TCM is a holistic approach that includes the use of herbal preparations, acupunctur...
Lynn Stephenson, Product Specialist, Sigma® Life Science and Chloe McClanahan, Product Manager, Sigma Life Science
Biofiles Vol. 8, No. 6
Keywords: Analgesics, Antitumor agents, Apoptosis, Cancer, Drug discovery, Fractionation, High performance liquid chromatography, Metabolites, Metabolomics, Nuclear magnetic resonance spectroscopy, Pharmaceutical
Elicitation of secondary metabolism in Hypericum perforatum by rhizosphere bacteria and derived elicitors in seedlings and shoot cultures. Mañero FJ, Algar E, Martín Gómez MS, et al. Pharm. Biol. 50(10), 1201-9, (2012)
The inhibition of lipopolysaccharide-induced macrophage inflammation by 4 compounds in Hypericum perforatum extract is partially dependent on the activation of SOCS3. Huang N, Rizshsky L, Hauck CC, et al. Phytochemistry 76, 106-16, (2012)
Identification of anti-inflammatory constituents in Hypericum perforatum and Hypericum gentianoides extracts using RAW 264.7 mouse macrophages. Huang N, Rizshsky L, Hauck C, et al. Phytochemistry 72(16), 2015-23, (2011)
In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts. Onoue S, Seto Y, Ochi M, et al. Phytochemistry 72(14-15), 1814-20, (2011)
Hypericin and pseudohypericin concentrations of a valuable medicinal plant Hypericum perforatum L. are enhanced by arbuscular mycorrhizal fungi. Zubek S, Mielcarek S, and Turnau K Mycorrhiza 22(2), 149-56, (2012)
Effects of UV-B on secondary metabolites of St. John's Wort (Hypericum perforatum L.) grown in controlled environments. Brechner ML, Albright LD, and Weston LA Photochem. Photobiol. 87(3), 680-4, (2011)
Positive correlations between hypericin and putative precursors detected in the quantitative secondary metabolite spectrum of Hypericum. Kusari S, Zühlke S, Borsch T, et al. Phytochemistry 70(10), 1222-32, (2009)
Pseudohypericin and hyperforin in Hypericum perforatum from Northern Turkey: variation among populations, plant parts and phenological stages. Cirak C, Radusiene J, Janulis V, et al. J. Integr. Plant Biol. 50(5), 575-80, (2008)
Inhibition of prostaglandin E(2) production by anti-inflammatory hypericum perforatum extracts and constituents in RAW264.7 Mouse Macrophage Cells. Hammer KD, Hillwig ML, Solco AK, et al. J. Agric. Food Chem. 55(18), 7323-31, (2007)
Inhibition of 17β-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols. Schwarz D, Kisselev P, Schunck WH, et al. Biochim. Biophys. Acta 1814(1), 168-74, (2011)
Determination of enantiomerization barriers of hypericin and pseudohypericin by dynamic high-performance liquid chromatography on immobilized polysaccharide-type chiral stationary phases and off-column racemization experiments. Ciogli A, Bicker W, and Lindner W Chirality 22(5), 463-71, (2010)
Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction. Hammer KD, Hillwig ML, Neighbors JD, et al. Phytochemistry 69(12), 2354-62, (2008)
Antiinflammatory and antioxidant activity of Hypericum rumeliacum Boiss. subsp. apollinis (Boiss. & Heldr.) Robson & Strid methanol extract. Galati EM, Contartese G, Miceli N, et al. Phytother Res. 22(6), 766-71, (2008)
1H NMR determination of hypericin and pseudohypericin in complex natural mixtures by the use of strongly deshielded OH groups. Tatsis EC, Exarchou V, Troganis AN, et al. Anal. Chim. Acta 607(2), 219-26, (2008)
The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug? Laggner H, Schreier S, Hermann M, et al. Free Radic. Res. 41(2), 234-41, (2007)
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