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H9627 Sigma

Hematoxylin

Synonym: Natural Black 1

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Cell Biology, G-H-I, Hematology and Histology,
mp   200 °C (dec.)(lit.)
solubility   95% ethanol: soluble1 mg/mL
Gene Information   rat ... Adora1(29290), Adora2a(25369)

Description

Packaging

25, 100 g in glass bottle

Price and Availability

TruPAGE™ Pre-cast Polyacrylamide Gels


TruPAGE™ Pre-cast Polyacrylamide GelsTruPAGE Gels run true every time!

  • . 2-Year Shelf Life
  • . Superior Band Resolution
  • . Strong & Tear Resistant
  • . Higher Capacity Wells


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Hematoxylin

certified by the Biological Stain Commission

Hematoxylin

for microscopy (Hist.), indicator (pH 5.0-6.0)

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
Safety Statements (Europe) 
26-36
WGK Germany 
3
RTECS 
MH7875000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

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The Effects Of Propofol On Hippocampal Caspase-3 And Bcl-2 Expression Following Forebrain Ischemia-reperfusion In Rats. Li, J., et al. Brain Res. 1356, 11-23, (2010)

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Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Yang ZJ Cancer Cell 14(2), 135-45, (2008)

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Synergy between inhibitors of androgen receptor and MEK has therapeutic implications in estrogen receptor-negative breast cancer. Naderi A Breast Cancer Res. 13(2), R36, (2011)

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By homing to the kidney, activated macrophages potently exacerbate renal injury. Wang Y, Wang Y, Cao Q, et al. Am. J. Pathol. 172(6), 1491-9, (2008)

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Concordance among pathologists in the second Cardiac Allograft Rejection Gene Expression Observational Study (CARGO II). Crespo-Leiro MG, Zuckermann A, Bara C, et al. Transplantation 94(11), 1172-7, (2012)

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Proliferation indices of phosphohistone H3 and Ki67: strong prognostic markers in a consecutive cohort with stage I/II melanoma. Nielsen PS, Riber-Hansen R, Jensen TO, et al. Mod. Pathol. 26(3), 404-13, (2013)

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Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. Wegiel B J. Natl. Cancer Inst. 100(14), 1022-36, (2008)

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Correlation of immunohistochemical staining p63 and TTF-1 with EGFR and K-ras mutational spectrum and diagnostic reproducibility in non small cell lung carcinoma. Thunnissen E, Boers E, Heideman DA, et al. Virchows Arch. 461(6), 629-38, (2012)

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Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A. Karen Zwaenepoel et al BMC Genomics 9, 393, (2008)

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Evaluation of Ki-67 and cyclin D1 expression in odontogenic keratocysts and orthokeratinised jaw cysts. Gani F, Mahomed F, and Meer S SADJ 67(7), 370-3, (2012)

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[Histochemical stains for minerals by hematoxylin-lake method]. Miyagawa M Rinsho Byori. 61(4), 313-7, (2013)

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Immunostaining: detection of signaling protein location in tissues, cells and subcellular compartments. Maity B, Sheff D, and Fisher RA Methods Cell Biol. 113, 81-105, (2013)

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An integrated approach for monitoring cell senescence. Pospelova TV, Chitikova ZV, and Pospelov VA Methods Mol. Biol. 965, 383-408, (2013)

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The immunohistochemistry and toluidine blue roles for Helicobacter pylori detection in patients with gastritis. Tajalli R, Nobakht M, Mohammadi-Barzelighi H, et al. Iran. Biomed. J. 17(1), 36-41, (2013)

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[Histostructural changes of rat cerebral cortex during hemorrhagic stroke modeling]. Savos'ko SI, Chaĭkovs'kyĭ IuB, Pogoriela NKh, et al. Fiziol. Zh. 58(5), 28-35, (2012)

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Laser capture microdissection for protein and NanoString RNA analysis. Golubeva Y, Salcedo R, Mueller C, et al. Methods Mol. Biol. 931, 213-57, (2013)

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Digitally reinforced polarization of hematoxylin-eosin in the diagnosis of renal amyloidosis. Sen S and Sarsik Kumbaraci B Turk. Patoloji Derg. 28(3), 204-12, (2012)

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[Model of chronic salmonellosis: parameters of infection and immune response in inbred mice genetically variable in susceptibility to salmonellosis]. Nesterenko LN, Kobets NV, and Balunets DV Zh. Mikrobiol. Epidemiol. Immunobiol. (4), 9-14, (2012)

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Characterization of the rabbit neonatal Fc receptor (FcRn) and analyzing the immunophenotype of the transgenic rabbits that overexpresses FcRn. Catunda Lemos AP PLoS ONE 7(1), e28869, (2012)

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High Expression of Complement Component 5 (C5) at Tumor Site Associates with Superior Survival in Ewing's Sarcoma Family of Tumour Patients. Savola S, Klami A, Myllykangas S, et al. ISRN Oncol. 2011, 168712, (2011)

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[Application of hematoxylin in histological technique]. Korzhevskiĭ DE Morfologiia. 132(6), 77-82, (2007)

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Transient exposure to transforming growth factor beta 3 improves the mechanical properties of mesenchymal stem cell-laden cartilage constructs in a density-dependent manner. Huang AH Tissue Eng. Part A 15(11), 3461-72, (2009)

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Immune responses and gene expression in hepatopancreas from Macrobrachium rosenbergii challenged by a novel pathogen spiroplasma MR-1008. Du J, Zhu H, Liu P, et al. Fish Shellfish Immunol. 34(1), 315-23, (2013)

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BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization. Forsman CL, Ng BC, Heinze RK, et al. Dev. Biol. 373(1), 95-106, (2013)

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Synthesis and biological evaluation of deoxy-hematoxylin derivatives as a novel class of anti-HIV-1 agents. Hideki Ishii et al Bioorg. Med. Chem. Lett. 22, 1469-74, (2012)

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The isolation and characterization of a novel telomerase immortalized first trimester trophoblast cell line, Swan 71. Shawn L. Straszewski-Chavez et al Placenta 30, 939-48, (2009)

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Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts. Pilling D PLoS ONE 4(10), e7475, (2009)

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Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer. Glen A Doherty et al BMC Cancer 9, 207, (2009)

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Sustained BMP signaling in osteoblasts stimulates bone formation by promoting angiogenesis and osteoblast differentiation. Fengjie Zhang et al J. Bone Miner Res. 24, 1224-33, (2009)

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Pathological changes associated with white striping in broiler breast muscles. Kuttappan VA, Shivaprasad HL, Shaw DP, et al. Poult. Sci. 92(2), 331-8, (2013)

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Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening. Li-Gen Lin et al J. Med. Chem. 51, 4419-29, (2008)

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Functional significance of VEGFR-2 on ovarian cancer cells. Spannuth WA Int. J. Cancer 124(5), 1045-53, (2009)

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Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome. Brantley-Sieders DM, Jiang A, Sarma K, et al. PLoS ONE 6(9), e24426, (2011)

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Sevelamer crystals in the gastrointestinal tract (GIT): a new entity associated with mucosal injury. Swanson BJ, Limketkai BN, Liu TC, et al. Am. J. Surg. Pathol. 37(11), 1686-93, (2013)

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Dominant role of the sst1 locus in pathogenesis of necrotizing lung granulomas during chronic tuberculosis infection and reactivation in genetically resistant hosts. Pichugin AV, Yan BS, Sloutsky A, et al. Am. J. Pathol. 174(6), 2190-201, (2009)

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A novel asymmetric 3D in-vitro assay for the study of tumor cell invasion. Brekhman V BMC Cancer 9, 415, (2009)

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Dystrophin-deficient cardiomyopathy in mouse: expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart. Spurney CF Neuromuscul. Disord. 18(5), 371-81, (2008)

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CYP1B1 expression in ovarian cancer in the laying hen Gallusdomesticus. Zhuge Y, Lagman JA, Ansenberger K, et al. Gynecol. Oncol. 112(1), 171-8, (2009)

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Activation of TLR3 in the trophoblast is associated with preterm delivery. Koga K Am. J. Reprod. Immunol. 61(3), 196-212, (2009)

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Localization of vascular adhesion protein-1 (VAP-1) in the human eye. Lama Almulki et al Exp. Eye Res. 90, 26-32, (2009)

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Multi-institutional comparison of whole slide digital imaging and optical microscopy for interpretation of hematoxylin-eosin-stained breast tissue sections. Krishnamurthy S, Mathews K, McClure S, et al. Arch. Pathol. Lab. Med. 137(12), 1733-9, (2013)

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Development of fluorescent polymerization-based signal amplification for sensitive and non-enzymatic biodetection in antibody microarrays. Heather J. Avens et al Acta Biomater. 6, 83-9, (2009)

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Cystatin B as a tissue and urinary biomarker of bladder cancer recurrence and disease progression. Feldman AS Clin. Cancer Res. 15(3), 1024-31, (2009)

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Changes in cell-cycle kinetics responsible for limiting somatic growth in mice. Chang M, Parker EA, Muller TJ, et al. Pediatr. Res. 64(3), 240-5, (2008)

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Determination of the fate and contribution of ex vivo expanded human bone marrow stem and progenitor cells for bone formation by 2.3ColGFP. Dezhong Yin et al Mol. Ther. 17, 1967-78, (2009)

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Three years after transplants in human mandibles, histological and in-line holotomography revealed that stem cells regenerated a compact rather than a spongy bone: biological and clinical implications. Giuliani A, Manescu A, Langer M, et al. Stem Cells Transl. Med. 2(4), 316-24, (2013)

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Rhomboid domain containing 2 (RHBDD2): a novel cancer-related gene over-expressed in breast cancer. MC Abba et al Biochim. Biophys. Acta 1792, 988-97, (2009)

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Overexpression of apoptotic cell removal receptor MERTK in alveolar macrophages of cigarette smokers. Kazeros A Am. J. Respir. Cell. Mol. Biol. 39(6), 747-57, (2008)

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SOD3 reduces inflammatory cell migration by regulating adhesion molecule and cytokine expression. Laurila, JP PLoS ONE 4(6), e5786, (2009)

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Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation. Woo J, Miletich I, Kim BM, et al. PLoS ONE 6(7), e22493, (2011)

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Transcriptional repression and inhibition of nuclear translocation of androgen receptor by diallyl trisulfide in human prostate cancer cells. Stan SD Clin. Cancer Res. 15(15), 4895-903, (2009)

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Epstein-barr virus-induced gene-3 is expressed in human atheroma plaques. Kempe S Am. J. Pathol. 175(1), 440-7, (2009)

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Gravity, a regulation factor in the differentiation of rat bone marrow mesenchymal stem cells. Yan Huang et al J. Biomed. Sci. 16, 87, (2009)

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Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut. Hemrajani C Infect. Immun. 76(11), 4804-13, (2008)

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Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression. Zhang XM, Li L, Xu JJ, et al. Gene 523(1), 82-7, (2013)

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Ultrastructural appearance and morphogenesis of renal glomerular hematoxylin bodies. Cohen AH and Zamboni L Am. J. Pathol. 89(1), 105-18, (1977)

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Hematoxylin and eosin tissue stain in Mohs micrographic surgery: a review. Larson K, Ho HH, Anumolu PL, et al. Dermatol. Surg. 37(8), 1089-99, (2011)

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Regeneration of limb joints in the axolotl (Ambystoma mexicanum). Lee J and Gardiner DM PLoS ONE 7(11), e50615, (2012)

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Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes. Standen CL Mol. Cell. Biol. 29(17), 4831-40, (2009)

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Elevated expression of catechol-O-methyltransferase is associated with labor and increased prostaglandin E(2) production by human fetal membranes. Harirah H Am. J. Obstet. Gynecol. 201(5), 496.e1-7, (2009)

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Semiautomated laser capture microdissection of lung adenocarcinoma cytology samples. Roy Chowdhuri S, Hanson J, Cheng J, et al. Acta Cytol. 56(6), 622-31, (2012)

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Histopathologic staining of low temperature cutaneous burns: comparing biomarkers of epithelial and vascular injury reveals utility of HMGB1 and hematoxylin phloxine saffron. Hirth DA, Singer AJ, Clark RA, et al. Wound Repair Regen. 20(6), 918-27, (2012)

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Use of magnetic nanoparticles to monitor alginate-encapsulated betaTC-tet cells. Constantinidis I, Grant SC, Simpson NE, et al. Magn. Reson. Med. 61(2), 282-90, (2009)

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Ex vivo dermoscopy for biobank-oriented sampling of melanoma. Malvehy J, Aguilera P, Carrera C, et al. JAMA Dermatol. 149(9), 1060-7, (2013)

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Beyond hematoxylin and eosin: the importance of immunohistochemical techniques for evaluating surgically resected constipated patients. Bassotti G, Villanacci V, Salerni B, et al. Tech. Coloproctol. 15(4), 371-5, (2011)

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Role of ldb1 in adult intestinal homeostasis. Dey-Guha I Int. J. Biol. Sci. 5(7), 686-94, (2009)

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Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine. Juyeon Lee et al J. Vet. Sci. 10, 177-80, (2009)

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Specific staining of tissue components with metal-hematoxylin complexes. Smith AA Micron 33(1), 95-103, (2002)

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Thin serial step sectioning of sentinel lymph node biopsy specimen may not be necessary to accurately stage the neck in oral squamous cell carcinoma. Bell RB, Markiewicz MR, Dierks EJ, et al. J. Oral Maxillofac. Surg. 71(7), 1268-77, (2013)

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Effect of interrupted eruption on the enamel organ of the rat incisor. Miwa T, Matsuzaka K, and Inoue T Zoology (Jena.) 116(2), 90-8, (2013)

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Visibility of Histoplasma within histiocytes on hematoxylin and eosin distinguishes disseminated histoplasmosis from other forms of pulmonary histoplasmosis. Mukhopadhyay S and Doxtader EE Hum. Pathol. 44(10), 2346-52, (2013)

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Is it really necessary to delay intranasal steroid treatment after FESS? An animal study. Bayraktar C, Atmaca S, Guvenc D, et al. Otolaryngol. Head Neck Surg. 148(2), 314-23, (2013)

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Participation of the oviductal s100 calcium binding protein G in the genomic effect of estradiol that accelerates oviductal embryo transport in mated rats. Mariana Ríos et al Reprod. Biol. Endocrinol. 9, 69, (2011)

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The long history of hematoxylin. Titford M Biotech. Histochem. 80(2), 73-8, (2005)

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Dynamic hypoxia in scar tissue during human hypertrophic scar progression. Zheng J, Song F, Lu SL, et al. Dermatol. Surg. 40(5), 511-8, (2014)

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Histological examination of ulcer margin for diagnosing Helicobacter pylori infection in patients with gastric ulcers. Lin MH, Cheng HT, Chuang WY, et al. Ann. Diagn. Pathol. 17(1), 63-6, (2013)

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Pulmonary fibrosis effect of ammonium perchlorate exposure in rabbit. Wu F, Chen H, Zhou X, et al. Arch. Environ. Occup. Health 68(3), 161-5, (2013)

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Hemorrhagic and serous-filled vesicles and bullae. Fracture blisters. Finklea LB and Becker LE JAMA Dermatol. 149(6), 751-6, (2013)

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Diffuse alveolar damage of the lungs in forensic autopsies: assessment of histopathological stages and causes of death. Nur Urer H, Ersoy G, and Yılmazbayhan ED ScientificWorldJournal 2012, 657316, (2012)

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Merck 14,4637

Beil. 17,V,8,469

Aldrich MSDS 1, 1001:C / Corp MSDS 1 (1), 1812:B / FT-IR 1 (2), 954:D / FT-IR 2 (3), 4208:D / IR-Spectra (3), 1444:H / RegBook 1 (2), 2839:D / Sax 6, 1495 / Sigma FT-IR 1 (2), 150:C / Stains and Dyes Ref, 394 / Structure Index 1, 455:B:6

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51260 Hematoxylin, for microscopy (Hist.), indicator (pH 5.0-6.0)

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