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H9784 Sigma

Hepatitis C virus NS4 antigen−Rhodamine

~1 mg/mL, ≥95% (SDS-PAGE), recombinant, expressed in E. coli, solution

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Properties

Related Categories AIDS and Viral Research Reagents, Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood, Immune System Regulation More...
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   solution
mol wt   mol wt 19 kDa (plus 114 kDa β-Gal tag)
concentration   ~1 mg/mL
shipped in   dry ice
storage temp.   −20°C
Gene Information   hepatitis C virus ... HCVgp1(951475)

Description

Biochem/physiol Actions

Positive control for HCV antibodies.

NS4 (non-structural 4) mainly acts a cofactor for the NS3 serine protease, which is needed for the cleavage of the non-structural area of the polyprotein. It also suppresses host cell translation as well as proliferation. In addition, it induces anti-inflammatory cytokines and thereby suppresses cellular immune responses.

General description

β-gal fused at N-terminus

HCVgp1 (hepatitis C virus glycoprotein 1), also referred to as polyprotein, is crucial for the induction of double-membrane vesicles, which are sites of HCV RNA amplification. The amino terminal of polyprotein contains the structural proteins core, envelope protein 1 (E1) and E2. The proteolytic cleavage of polyprotein results in the formation of 10 mature viral proteins, including NS4 (non-structural 4).

Other Notes

HCV NS4a+b [1658-1863]-Galactosidase-tagged, rhodamine conjugate.

Physical form

Solution in 8 M urea, 20 mM tris-HCl, pH 8.0, and 10 mM 2-mercaptoethanol.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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