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H9784 Sigma

Hepatitis C virus NS4 antigen−Rhodamine

~1 mg/mL, ≥95% (SDS-PAGE), recombinant, expressed in E. coli, solution



Related Categories AIDS and Viral Research Reagents, Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood, Immune System Regulation More...
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   solution
mol wt   mol wt 19 kDa (plus 114 kDa β-Gal tag)
concentration   ~1 mg/mL
shipped in   dry ice
storage temp.   −20°C
Gene Information   hepatitis C virus ... HCVgp1(951475)


Biochem/physiol Actions

Positive control for HCV antibodies.

NS4 (non-structural 4) mainly acts a cofactor for the NS3 serine protease, which is needed for the cleavage of the non-structural area of the polyprotein. It also suppresses host cell translation as well as proliferation. In addition, it induces anti-inflammatory cytokines and thereby suppresses cellular immune responses.

General description

β-gal fused at N-terminus

HCVgp1 (hepatitis C virus glycoprotein 1), also referred to as polyprotein, is crucial for the induction of double-membrane vesicles, which are sites of HCV RNA amplification. The amino terminal of polyprotein contains the structural proteins core, envelope protein 1 (E1) and E2. The proteolytic cleavage of polyprotein results in the formation of 10 mature viral proteins, including NS4 (non-structural 4).

Other Notes

HCV NS4a+b [1658-1863]-Galactosidase-tagged, rhodamine conjugate.

Physical form

Solution in 8 M urea, 20 mM tris-HCl, pH 8.0, and 10 mM 2-mercaptoethanol.

Price and Availability

All labs need water
Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers


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