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H9785 Sigma

HVEM/Fc Chimera human

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: ATAR, Herpes virus entry mediator, TR2



Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, TNF Receptors,
recombinant   expressed in NSO cells
assay   >90% (SDS-PAGE)
form   lyophilized powder
mol wt   mol wt 60 kDa by SDS-PAGE
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   human ... TNFRSF14(8764)


Analysis Note

The biological activity is measured by its ability to inhibit TNF-β-mediated cytotoxicity in mouse L929 cells The ED50 is 2.5-10 μg/ml in cells treated with 1 ng/ml of recombinant human TNF-β.

Other Notes

Extracellular domain fused to the C-terminal 6X histidine-tagged region of human IgG1.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing 5 mg bovine serum albumin.

Biochem/physiol Actions

HVEM (herpes virus entry mediator A) associates with the immunoglobulin (Ig) superfamily members and TNF (tumor necrosis factor) superfamily members. It is involved in the innate as well as acquired immunity. HVEM is expressed in many malignancies.

Type I membrane protein belonging to the TNF/NGF receptor superfamily. Interacts directly with the herpes simplex virus envelope glycoprotein D.

General description

HVEM (herpes virus entry mediator A) belongs to the tumor necrosis factor (TNF) receptor superfamily. It is widely expressed in cells, such as T cells, B cells, natural killer cells, dendritic cells and myeloid cells. It is also present in nonlymphoid organs. The gene is mapped to human chromosome 1p36.

Price and Availability

All labs need water
Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers


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