Synonym: Anti-Pancreatic secretory granule membrane major glycoprotein GP2 precursor, Anti-Pancreatic zymogen granule membrane protein GP-2, Anti-ZAP75
Human Protein Atlas Number HPA016668 Human Protein Atlas characterization data
|Related Categories||Alphabetical Index, Antibodies, GO-GZ, GP-GP, Prestige Antibodies,|
|application(s)||immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable|
|protein array: suitable|
|antibody form||affinity isolated antibody|
|form||buffered aqueous glycerol solution|
|grade||Prestige Antibodies® Powered by Atlas Antibodies|
|shipped in||wet ice|
|Gene Information||human ... GP2(2813)|
Pancreatic secretory granule membrane major glycoprotein GP2 precursor recombinant protein epitope signature tag (PrEST)
GP-2 is a membrane glycoprotein that is found in the secretory granules of the pancreatic exocrine components. This glycoprotein may modulate membrane transport in the acinar cells of the pancreas. GP-2 acts as an autoantigen in Crohn’s disease, thereby contributing to the pathogenesis of autoinflammatory responses associated with inflammatory bowel diseases 1,2,3. Anti-GP2 antibody is specific for GP-2 in humans.
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
Anti-GP2 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using protein array and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC
Certificate of Analysis
Certificate of Origin
|Personal Protective Equipment||Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)|
A large number of the Prestige Antibodies® have been used in subcellular localization studies by immunofluorescence (IF) staining of three cell lines: A-431, U-2 OS, and U-251MG. Each cell line is st...
Keywords: Immunofluorescence, Immunostaining, Molecular probes, Sample preparations
The Prestige Antibodies® are subjected to a standardized test procedure using specially designed tissue microarray (TMA) slides.
Keywords: Buffers, Dehydration reaction, Hydration reaction, Immunostaining, Microarray Analysis, PAGE, Tissue microarrays
The binding specificity of the purified Prestige Antibodies® is determined on protein arrays, using PrEST protein fragments, to ensure high specificity toward its antigen and low background binding.
Keywords: Microarray Analysis, Molecular probes
Some Prestige Antibodies® are verified as primary reagents for Western blot analysis using the described procedure.
Keywords: Catalytic combustion detector, Electrophoresis, Gene expression, Sample preparations, Western blot
As a leading supplier of antibodies, Sigma® Life Science is committed to providing researchers the antibody they need with the quality they deserve. Our Antibody Explorer Search Tool provides easy ac...
Keywords: Buffers, Cell biology, Epigenetics, Immunohistochemistry, Immunoprecipitation, Molecular biology, Neuroscience, Western blot
2. Molecular cloning and sequences of cDNAs encoding α (large) and β (small) isoforms of human pancreatic zymogen granule membrane-associated protein GP2. Fukuoka, S. Biochim. Biophys. Acta 1491(1-3), 376-80, (2000)
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