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I0281 Sigma

Interleukin-4/Fc Chimera (non-lytic) from mouse

>98% (SDS-PAGE), recombinant, expressed in CHO cells, buffered aqueous solution

Synonym: IL-4:Fc (non-lytic)

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Properties

Related Categories Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines & Growth Factors,
recombinant   expressed in CHO cells
assay   >98% (SDS-PAGE)
form   buffered aqueous solution
mol wt   mol wt 98 kDa
impurities   endotoxin, tested
shipped in   wet ice
storage temp.   −20°C
Gene Information   mouse ... Il4(16189)

Description

Biochem/physiol Actions

Possesses the biological functions of the IL-4 moiety and a prolonged circulating half-life determined by the Fc domain.

In mice, absence of IL-4 (interleukin-4) causes anxiety-like behavior. It is secreted by Th2 (T helper) cells and works as a pro-inflammatory cytokine. It plays an important role in immune response and allergic diseases. It is also associated with schistosoma mansoni pulmonary hypertension.

Other Notes

Dimeric fusion protein consisting of mouse IL-4 fused to mutant mouse Fcγ2a Fc.

Physical form

Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.

Price and Availability

Safety & Documentation

Safety Information

WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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