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I0529 Sigma

Anti-Interleukin-16 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-IL-16

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Interleukins (IL),
species reactivity   human
application(s)   indirect ELISA: 0.5-1.0 μg/mL
  western blot: 0.1-0.2 μg/mL
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... IL16(3603)
biological source   goat
conjugate   unconjugated

Description

Immunogen

recombinant human IL-16 expressed in E. coli.

General description

Interleukin-16 is also known as lymphocyte chemoattractant factor (LCF) and acts as chemoattractant for human T cells. IL-16 is secreted by cells of immune system such as T cells, dendritic cells and eosinophils. It is also secreted by the non-immune cells such as endothelial cells, fibroblasts and neurons. IL-16 is biologically active in the multimeric form and binds to CD4 and CCR5 receptors. The signaling induced by IL-16 activates pathways that involve MAPK, PI3K and SAPK. The biological activities of IL-16 are important for inflammation, migration, cell cycle progression, cell proliferation, development of Th1 cells and regulation of T cell responses. IL-16 signaling is important in the pathophysiology of Crohn′s disease, HIV infection, airway inflammation in asthma and rheumatoid arthritis. Anti-Interleukin-16 antibody recognizes human IL-16.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Application

Anti-Interleukin-16 antibody may be used for immunoblotting at a working antibody concentration of 0.1-0.2 μg/ml. For ELISA, a working concentration of 0.5-1.0 μg/ml is recommended.

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